Choroid plexus aging: structural and vascular insights from the HCP-aging dataset

The choroid plexus (ChP), a highly vascularized structure within the ventricles, is essential for cerebrospinal fluid (CSF) production and metabolic waste clearance, crucial for neurofluid homeostasis and cognitive function. ChP enlargement is seen in normal aging and neurodegenerative diseases like...

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Bibliographic Details
Published in:Fluids and barriers of the CNS 2024-12, Vol.21 (1), p.98-12
Main Authors: Sun, Zhe, Li, Chenyang, Zhang, Jiangyang, Wisniewski, Thomas, Ge, Yulin
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aging
Aging - physiology
Alzheimer's disease
Choroid plexus
Choroid Plexus - blood supply
Choroid Plexus - diagnostic imaging
Cogeneration power plants
Connectome
Datasets as Topic
Diffusion Magnetic Resonance Imaging - methods
Female
Human connectome project
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Nervous system diseases
Perfusion function
Vascular degeneration
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Summary:The choroid plexus (ChP), a highly vascularized structure within the ventricles, is essential for cerebrospinal fluid (CSF) production and metabolic waste clearance, crucial for neurofluid homeostasis and cognitive function. ChP enlargement is seen in normal aging and neurodegenerative diseases like Alzheimer's disease (AD). Despite its key role of in the blood-CSF barrier (BCSFB), detailed studies on age-related changes in its perfusion and microstructure remain limited. We analyzed data from 641 healthy individuals aged between 36 and 90, using the Human Connectome Project Aging (HCP-A) dataset. Volumetric, perfusion, and diffusion metrics of the ChP were derived from structural MRI, arterial spin labeling (ASL), and diffusion-weighted imaging (DWI), respectively. Partial correlations were used to explore age-related ChP changes, and independent t-tests to examine sex differences across age decades. One-way ANOVA was employed to compare perfusion characteristics among ChP, gray matter (GM), and white matter (WM). Relationships between volume, perfusion, and diffusion were investigated, adjusting for age and sex. Additionally, the distribution of cyst-like structures within the ChP and their diffusion/perfusion MRI characteristics were analyzed across different age groups. The ChP undergoes notable changes with age, including an increase in volume (r  = 0.2, P 
ISSN:2045-8118
2045-8118
DOI:10.1186/s12987-024-00603-y