Spirulina supplement and exercise training affect lipid droplets-related genes expression in visceral adipose tissue

Disruption of lipid droplets (LDs) is associated with many metabolic diseases. Spirulina, as a natural bioactive dietary supplement, along with exercise training, may improve lipid metabolism; however, their effects on LDs-regulated genes in visceral adipose tissue are still unclear. This study aime...

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Bibliographic Details
Published in:Avicenna journal of phytomedicine 2024-01, Vol.14 (1), p.100-111
Main Authors: Shahandeh, Fariba, Fathi, Rozita, Nasiri, Khadijeh
Format: Article
Language:English
Subjects:
exercise
gene expression
lipid droplets
Original
rab18
spirulina
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Summary:Disruption of lipid droplets (LDs) is associated with many metabolic diseases. Spirulina, as a natural bioactive dietary supplement, along with exercise training, may improve lipid metabolism; however, their effects on LDs-regulated genes in visceral adipose tissue are still unclear. This study aimed to investigate the effects of six-week Spirulina supplementation along with exercise training on LDs regulating gene expression. Fifty-six male Wistar rats were divided into six groups: saline (control), control+Spirulina (Spirulina), aerobic interval training (AIT), AIT+ Spirulina (AIT+Spirulina), resistance training and resistance+ Spirulina. The supplement groups consumed 500 mg/kg Spirulina five days per week. The training groups performed AIT (5 times per week) and resistance training (3 times per week) for 6 weeks. LDs regulating genes expression in visceral adipose tissue ( , , , , , , and ) was analyzed by real-time PCR. Spirulina and exercise training had no significant effects on the gene expression of Syntaxin18 (p=0.69) and (p=0. 84), (p=0.98), or (p=0.58). In addition, Spirulina was found to significantly attenuate the expression of (p=0.01) and (p=0.01) genes compared to the control, AIT, and resistance training groups. However, gene expression was higher in the resistance training than the AIT. Furthermore, Spirulina decreased (p=0.03) gene expression in visceral adipose tissue compared to the control, AIT, and resistance training groups. Unexpectedly, Spirulina supplementation decreased the expression of these genes even more when taken without exercise training. Spirulina supplementation and exercise training have significant effects on LDs-regulated genes in visceral adipose tissue.
ISSN:2228-7930
2228-7949
DOI:10.22038/AJP.2023.22915