Case Report: Detection of Symptomatic Treatment-Related Changes in a Patient With Anaplastic Oligodendroglioma Using FET PET

Following local and systemic treatment of gliomas, the differentiation between glioma relapse and treatment-related changes such as pseudoprogression or radiation necrosis using conventional MRI is limited. To overcome this limitation, various amino acid PET tracers such as O -[2-( 18 F)-fluoroethyl...

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Bibliographic Details
Published in:Frontiers in oncology 2021-11, Vol.11
Main Authors: Bauer, Elena Katharina, Werner, Jan-Michael, Fink, Gereon R., Langen, Karl-Josef, Galldiks, Norbert
Format: Article
Language:English
Subjects:
amino acid PET
chemoradiation
diagnostic challenge
oligodendroglioma
Oncology
pseudoprogression
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Summary:Following local and systemic treatment of gliomas, the differentiation between glioma relapse and treatment-related changes such as pseudoprogression or radiation necrosis using conventional MRI is limited. To overcome this limitation, various amino acid PET tracers such as O -[2-( 18 F)-fluoroethyl]-L-tyrosine (FET) are increasingly used and provide valuable additional clinical information. We here report neuroimaging findings in a clincally symptomatic 53-year-old woman with a recurrent anaplastic oligodendroglioma with MRI findings highly suspicious for tumor progression. In contrast, FET PET imaging suggested treatment-related changes considerably earlier than the regression of contrast enhancement on MRI. In patients with oligodendroglioma, the phenomenon of symptomatic treatment-related changes is not well described, making these imaging findings unique and important for clinical decision-making.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.735388