Sulfated and non-sulfated chondroitin affect the composition and metabolism of human colonic microbiota simulated in an in vitro fermentation system

Chondroitin sulfate (CS) is a family of glycosaminoglycans and have a wide range of applications in dietary supplements and pharmaceutical drugs. In this study, we evaluated the effects of several types of CS, differing in their sulfated positions, on the human colonic microbiota and their metabolit...

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Published in:Scientific reports 2023-07, Vol.13 (1), p.12313-12313, Article 12313
Main Authors: Inokuma, Kentaro, Sasaki, Daisuke, Kurata, Kaoru, Ichikawa, Megumi, Otsuka, Yuya, Kondo, Akihiko
Format: Article
Language:English
Subjects:
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631/326/41
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692/4020/2199
Bacteroides
Chondroitin sulfate
Chondroitin Sulfates
Dietary supplements
Eubacterium
Feces
Fermentation
Glycosaminoglycans
Humanities and Social Sciences
Humans
Intestinal microflora
Metabolites
Microbiota
multidisciplinary
Ornithine
Relative abundance
Science
Science (multidisciplinary)
Sulfates
Sulfur Oxides
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Summary:Chondroitin sulfate (CS) is a family of glycosaminoglycans and have a wide range of applications in dietary supplements and pharmaceutical drugs. In this study, we evaluated the effects of several types of CS, differing in their sulfated positions, on the human colonic microbiota and their metabolites. CS (CSA, CSC, and CSE) and non-sulfated chondroitin (CH) were added into an in vitro human colonic microbiota model with fecal samples from 10 healthy individuals. CS addition showed a tendency to increase the relative abundance of Bacteroides , Eubacterium , and Faecalibacterium , and CSC and CSE addition significantly increased the total number of eubacteria in the culture of the Kobe University Human Intestinal Microbiota Model. CSE addition also resulted in a significant increase in short-chain fatty acid (SCFA) levels. Furthermore, addition with CSC and CSE increased the levels of a wide range of metabolites including lysine, ornithine, and Ile-Pro-Pro, which could have beneficial effects on the host. However, significant increases in the total number of eubacteria, relative abundance of Bacteroides , and SCFA levels were also observed after addition with CH, and the trends in the effects of CH addition on metabolite concentrations were identical to those of CSC and CSE addition. These results provide novel insight into the contribution of the colonic microbiota to the beneficial effects of dietary CS.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-38849-5