Increased resting-state alpha coherence and impaired inhibition control in young smokers

• Published in: Frontiers in neuroscience 2022-11, Vol.16, p.1026835
• Main Authors: Wang, Zhengxi, Dong, Fang, Sun, Yaning, Wang, Juan, Zhang, Ming, Xue, Ting, Ren, Yan, Lv, Xiaoqi, Yuan, Kai, Yu, Dahua
• Format: Article
• Language: English
• Subjects: alpha coherence; Go/NoGo task; inhibition ability; Neuroscience; resting state; young smokers
• ISSN: 1662-4548; 1662-453X; 1662-453X
• DOI: 10.3389/fnins.2022.1026835

Exposure to nicotine is the first cause of entirely preventable death killing, which is commonly initiated in adolescence. Previous studies revealed the changes of electroencephalography (EEG) and inhibition control in smokers. However, little is known about the specific link between alpha coherence during the resting state and inhibition control ability in young smokers. The present study aimed to investigate inter-hemispherical and frontal-parietal alpha coherence changes and assessed the relationships between alpha coherence and inhibition control in young smokers. We collected resting-state EEG data from 23 young smokers and 24 healthy controls. Inhibition control ability was assessed by a Go/NoGo task. Compared to healthy controls, young smokers exhibited increased inter-hemispherical and frontal-parietal alpha coherence. Furthermore, young smokers committed more NoGo errors in the Go/NogGo task. It is noteworthy that alpha coherence at the frontal electrode sites was positively correlated with NoGo errors in healthy controls, whereas inverse correlations were observed in young smokers. Our findings suggested that alterations of alpha coherence may provide support to the earlier nicotine-dependence-related research findings, which may help us to understand the neuropathology of inhibitory control in young smokers.