Extracellular Vesicle Therapy for Type 1 Diabetes

Type 1 diabetes (T1D) is a chronic disorder characterized by immune-mediated destruction of pancreatic insulin-producing β-cells. The primary treatment for T1D is multiple daily insulin injections to control blood sugar levels. Cell-free delivery packets with therapeutic properties, extracellular ve...

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Bibliographic Details
Published in:Frontiers in immunology 2022-04, Vol.13, p.865782-865782
Main Authors: Soltani, Setareh, Mansouri, Kamran, Emami Aleagha, Mohammad Sajad, Moasefi, Narges, Yavari, Niloofar, Shakouri, Seyed Kazem, Notararigo, Sara, Shojaeian, Ali, Pociot, Flemming, Yarani, Reza
Format: Article
Language:English
Subjects:
Diabetes Mellitus, Type 1 - therapy
exosomes
extracellular vesicle
Extracellular Vesicles
Humans
Immunology
Immunomodulation
Insulin
Insulin-Secreting Cells
therapy
type 1 diabetes
β-cell
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Description
Summary:Type 1 diabetes (T1D) is a chronic disorder characterized by immune-mediated destruction of pancreatic insulin-producing β-cells. The primary treatment for T1D is multiple daily insulin injections to control blood sugar levels. Cell-free delivery packets with therapeutic properties, extracellular vesicles (EVs), mainly from stem cells, have recently gained considerable attention for disease treatments. EVs provide a great potential to treat T1D ascribed to their regenerative, anti-inflammatory, and immunomodulatory effects. Here, we summarize the latest EV applications for T1D treatment and highlight opportunities for further investigation.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.865782