Assessment of Selected Matrix Metalloproteinases (MMPs) and Correlation with Cytokines in Psoriatic Patients

Metalloproteinases (MMPs) and cytokines have a great impact on the pathogenesis of psoriasis. Cytokines, as key mediators of inflammation and autoimmune processes, play a crucial role in the regulation of MMP expression in different cell types. Parallel, MMPs have an influence on cytokine production...

Full description

Saved in:
Bibliographic Details
Published in:Mediators of inflammation 2021, Vol.2021, p.9913798-8
Main Authors: Michalak-Stoma, Anna, Bartosińska, Joanna, Raczkiewicz, Dorota, Kowal, Małgorzata, Krasowska, Dorota, Chodorowska, Grażyna
Format: Article
Language:English
Subjects:
Age
Arthritis
Arthritis, Psoriatic
Cytokines
Cytokines - metabolism
Dermatology
Fibroblasts
Gelatinase B
Helper cells
Humans
Inflammation
Interleukin 12
Interleukin 4
Interstitial collagenase
Lymphocytes T
Matrix metalloproteinase
Neutrophils
Pathogenesis
Psoriasis
Psoriatic arthritis
Skin
Sociodemographics
Statistical analysis
Stromelysin 1
Stromelysin 2
Th17 Cells - metabolism
Tumor Necrosis Factor-alpha - metabolism
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Metalloproteinases (MMPs) and cytokines have a great impact on the pathogenesis of psoriasis. Cytokines, as key mediators of inflammation and autoimmune processes, play a crucial role in the regulation of MMP expression in different cell types. Parallel, MMPs have an influence on cytokine production. This interaction was not well recognized in psoriatic patients. Our study is aimed at assessing the selected serum MMP levels and their correlations with cytokine levels in the serum of psoriatic patients. We observed a significantly elevated level of pro-MMP-1 and MMP-9 in psoriatic patients’ serum in comparison to the control group. We did not observe any statistically significant differences of MMP-3 and pro-MMP-10 between the psoriatic patients and the control group. We did not observe any statistically significant differences in all the studied MMP levels between the patients with and without psoriatic arthritis (PsA). MMP-3 level correlated positively with proinflammatory cytokines, i.e., IL-12p/70, IL-17A, and TNF-α as well as MMP-3 and pro MMP-1 correlated positively with IL-4 in the psoriatic patients. In the control group, a positive correlation between pro-MMP-1 and TNF-α was found. These results confirm MMPs and Th1 and Th17 cytokine interaction in the inflammatory regulation in psoriasis.
ISSN:0962-9351
1466-1861
DOI:10.1155/2021/9913798