Trajectory of left ventricular geometry and diastolic dysfunction in hereditary transthyretin cardiac amyloidosis

Amyloid transthyretin (ATTR) depositions cause left ventricular (LV) hypertrophy, diastolic dysfunction, and heart failure. The time course of changes in LV geometry and diastolic dysfunction has not been fully reported in patients with ATTR cardiomyopathy. A 79‐year‐old woman with previous myocardi...

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Bibliographic Details
Published in:ESC Heart Failure 2021-08, Vol.8 (4), p.3422-3426
Main Authors: Akatsuka, Tatsuya, Fujimoto, Naoki, Ishiyama, Masaki, Nakamori, Shiro, Imanaka‐Yoshida, Kyoko, Dohi, Kaoru
Format: Article
Language:English
Subjects:
Amyloid
Amyloidosis
Cardiac transthyretin amyloidosis
Cardiomyopathy
Carpal tunnel syndrome
Case Report
Case Reports
Dyspnea
Ejection fraction
Heart failure
Left ventricular function
Magnetic resonance imaging
Morphology
Mutation
Patients
Pressure–volume relationships
Scintigraphy
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Description
Summary:Amyloid transthyretin (ATTR) depositions cause left ventricular (LV) hypertrophy, diastolic dysfunction, and heart failure. The time course of changes in LV geometry and diastolic dysfunction has not been fully reported in patients with ATTR cardiomyopathy. A 79‐year‐old woman with previous myocardial infraction presented with shortness of breath on exertion, and progressive bilateral lower extremity weakness and polyneuropathy. She was diagnosed with Val30Met hereditary ATTR cardiomyopathy by cardiac biopsy and genetic testing. During the past 5 year period, significant LV concentric remodelling with small LV cavity occurred, resulting in an increased LV stiffness and prolonged LV relaxation. This case report highlights the time course of changes in LV geometry and diastolic function and the importance of early diagnosis of ATTR cardiomyopathy.
ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.13454