Generation of human embryonic stem cell lines (WAe001-A-67,WAe001-A-68) with TEAD1 and TEAD4 expression by the PiggyBac transposon system

Transcription factors TEAD1 and TEAD4 play an important role in development, differentiation, cell growth and proliferation. To further understand the exact role of TEAD1 and TEAD4 in these processes. We generated TEAD1 and TEAD4 doxycycline-inducible expression human embryonic stem cell lines (WAe0...

Full description

Saved in:
Bibliographic Details
Published in:Stem cell research 2021-07, Vol.54, p.102408-102408, Article 102408
Main Authors: Quan, Yingyi, Jin, Peifeng, Ma, Jianshe, Yang, Jiwen, Wang, Zuxuan, Zhang, Huan, Hu, Minjie, Fan, Junming, Fan, Xiaofang, Gong, Yongsheng, Li, Ming, Wang, Yongyu
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Transcription factors TEAD1 and TEAD4 play an important role in development, differentiation, cell growth and proliferation. To further understand the exact role of TEAD1 and TEAD4 in these processes. We generated TEAD1 and TEAD4 doxycycline-inducible expression human embryonic stem cell lines (WAe001-A-67 and WAe001-A-68) by PiggyBac transposon system. These cell lines retained normal morphology and karyotype, normal expression of pluripotent markers, and differentiation potential. These cell lines can be used to verify whether the TEAD1 and TEAD4 play a role in stem cell and cell lineage differentiation.
ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2021.102408