Hypothyroidism in Pancreatic Cancer: Role of Exogenous Thyroid Hormone in Tumor Invasion-Preliminary Observations

According to the epidemiological studies, about 4.4% of American general elderly population has a pronounced hypothyroidism and relies on thyroid hormone supplements daily. The prevalence of hypothyroidism in our patients with pancreatic cancer was much higher, 14.1%. A retrospective analysis was pe...

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Bibliographic Details
Published in:Journal of Thyroid Research 2016-01, Vol.2016 (2016), p.10-16
Main Authors: Arafat, Hwyda A., Chipitsyna, Galina I., Kang, Christopher Y., Saxena, Shivam, Gandhi, Ankit V., Sarosiek, Konrad, Yeo, Charles J.
Format: Article
Language:English
Subjects:
Age
Body mass index
Breast cancer
Care and treatment
Cell adhesion & migration
Cell growth
Complications and side effects
Data collection
Females
Hormones
Hospitals
Hypothyroidism
Males
Medical prognosis
Pancreatic cancer
Pathology
Patients
Risk factors
Steroid hormones
Studies
Survival analysis
Thyroid gland
Thyroid hormones
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Summary:According to the epidemiological studies, about 4.4% of American general elderly population has a pronounced hypothyroidism and relies on thyroid hormone supplements daily. The prevalence of hypothyroidism in our patients with pancreatic cancer was much higher, 14.1%. A retrospective analysis was performed on patients who underwent pancreaticoduodenectomy (Whipple procedure) or distal pancreatectomy and splenectomy (DPS) at Thomas Jefferson University Hospital, Philadelphia, from 2005 to 2012. The diagnosis of hypothyroidism was correlated with clinicopathologic parameters including tumor stage, grade, and survival. To further understand how thyroid hormone affects pancreatic cancer behavior, functional studies including wound-induced cell migration, proliferation, and invasion were performed on pancreatic cancer cell lines, MiaPaCa-2 and AsPC-1. We found that hypothyroid patients taking exogenous thyroid hormone were more than three times likely to have perineural invasion, and about twice as likely to have higher T stage, nodal spread, and overall poorer prognostic stage ( P < 0.05 ). Pancreatic cancer cell line studies demonstrated that exogenous thyroid hormone treatment increased cell proliferation, migration, and invasion ( P < 0.05 ). We conclude that exogenous thyroid hormone may contribute to the progression of pancreatic cancer.
ISSN:2042-0072
2090-8067
2042-0072
DOI:10.1155/2016/2454989