The Macroautophagy Machinery in MHC Restricted Antigen Presentation

Autophagy-related (ATG) gene products regulate macroautophagy, LC3-associated phagocytosis (LAP) and LC3-dependent extracellular vesicle loading and secretion (LDELS). These processes also influence antigen processing for presentation on major histocompatibility complex (MHC) molecules to T cells. H...

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Bibliographic Details
Published in:Frontiers in immunology 2021-02, Vol.12, p.628429
Main Author: Münz, Christian
Format: Article
Language:English
Subjects:
Animals
Antigen Presentation
Autoimmunity
Autophagosomes - metabolism
Autophagy - immunology
cross-presentation
cytotoxic CD8+ T cells
exocytosis
Extracellular Vesicles - metabolism
helper CD4+ T cells
Histocompatibility Antigens Class II - metabolism
Humans
Immunology
Immunomodulation
Infections - immunology
LC3-associated phagocytosis
Lymphocyte Activation
Microtubule-Associated Proteins - metabolism
Neoplasms - immunology
T-Lymphocytes - immunology
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Summary:Autophagy-related (ATG) gene products regulate macroautophagy, LC3-associated phagocytosis (LAP) and LC3-dependent extracellular vesicle loading and secretion (LDELS). These processes also influence antigen processing for presentation on major histocompatibility complex (MHC) molecules to T cells. Here, I summarize how these different pathways use the macroautophagy machinery, contribute to MHC class I and II restricted antigen presentation and influence autoimmunity, tumor immunology and immune control of infectious diseases. Targeting these different pathways should allow the regulation of intracellular and extracellular antigen presentation to T cells to modulate protective and pathological immune responses.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.628429