Low 1,5-anhydroglucitol levels are associated with long-term cardiac mortality in acute coronary syndrome patients with hemoglobin A1c levels less than 7.0

• Published in: Cardiovascular diabetology 2017-11, Vol.16 (1), p.151-9, Article 151
• Main Authors: Ouchi, Shohei, Shimada, Kazunori, Miyazaki, Tetsuro, Takahashi, Shuhei, Sugita, Yurina, Shimizu, Megumi, Murata, Azusa, Kadoguchi, Tomoyasu, Kato, Takao, Aikawa, Tatsuro, Suda, Shoko, Sai, Eiryu, Hiki, Masaru, Iwata, Hiroshi, Kasai, Takatoshi, Miyauchi, Katsumi, Daida, Hiroyuki
• Format: Article
• Language: English
• Subjects: 1,5-anhydroglucitol; Acute coronary syndrome; Acute Coronary Syndrome - blood; Acute Coronary Syndrome - diagnostic imaging; Acute Coronary Syndrome - mortality; Acute coronary syndromes; Aged; Aged, 80 and over; Angina pectoris; Angiography; Atherosclerosis; Biomarkers - blood; Blood Glucose - metabolism; Cardiac mortality; Cardiovascular disease; Cardiovascular diseases; Cause of Death; Chi-Square Distribution; Cholesterol; Cirrhosis; Coronary Angiography; Coronary artery; Coronary vessels; Deoxyglucose - blood; Diabetes; Diabetes mellitus; Diabetic retinopathy; Disease-Free Survival; Down-Regulation; Family medical history; Fatalities; Female; Gastrectomy; Glomerular filtration rate; Glucose transporter; Glycated Hemoglobin - metabolism; Health risks; Heart attacks; Hemoglobin; Hospitals, University; Humans; Hyperglycemia; Hyperglycemia - blood; Hyperglycemia - diagnosis; Hyperglycemia - mortality; Hypertension; Implants; Japan; Kaplan-Meier Estimate; Kidney diseases; Kidneys; Kinases; Liver; Liver cirrhosis; Low density lipoprotein; Male; Malignancy; Medical imaging; Medical records; Middle Aged; Mortality; Multivariate Analysis; Original Investigation; Patients; Postprandial hyperglycemia; Postprandial Period; Proportional Hazards Models; Regression analysis; Retrospective Studies; Risk Factors; Stenosis; Steroids; Thromboembolism; Thrombosis; Time Factors; Triglycerides
• ISSN: 1475-2840; 1475-2840
• DOI: 10.1186/s12933-017-0636-1

Diabetes mellitus is considered an important risk factor for cardiovascular diseases. High hemoglobin A1c (HbA1c) levels, which indicate poor glycemic control, have been associated with occurrence of cardiovascular diseases. There are few parameters which can predict cardiovascular risk in patients with well-controlled diabetes. Low 1,5-anhydroglucitol (1,5-AG) levels are considered a clinical marker of postprandial hyperglycemia. We hypothesized that low 1,5-AG levels could predict long-term mortality in acute coronary syndrome (ACS) patients with relatively low HbA1c levels. The present study followed a retrospective observational study design. We enrolled 388 consecutive patients with ACS admitted to the cardiac intensive care unit at the Juntendo University Hospital from January 2011 to December 2013. Levels of 1,5-AG were measured immediately before emergency coronary angiography. Patients with early stent thrombosis, no significant coronary artery stenosis, malignancy, liver cirrhosis, a history of gastrectomy, current steroid treatment, moderately to severely reduced kidney function (estimated glomerular filtration rate