Suppressive Mechanisms Induced by Tregs in Celiac Disease

Celiac disease (CD) is a systemic immune-mediated disorder caused by the dietary gluten in individuals who are genetically susceptible to the disease. In fact, CD is a T cell-mediated immune disease in which gluten-derived peptides activate the lamina propria CD4+ Teff cells, and these T-cell subset...

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Bibliographic Details
Published in:Iranian biomedical journal 2020-05, Vol.24 (3), p.140-147
Main Authors: Asri, Nastaran, Rostami-Nejad, Mohammad, Barzegar, Mohammad, Nikzamir, Abdolrahim, Rezaei-Tavirani, Mostafa, Razzaghi, Mohammadreza, Zali, Mohammad Reza
Format: Article
Language:English
Subjects:
Antigen-Presenting Cells - immunology
Autoimmune diseases
Biomarkers - metabolism
CD25 antigen
CD4 antigen
Celiac disease
Celiac Disease - immunology
Cytokines - metabolism
Diet
Disease
Forkhead protein
Foxp3 protein
Gluten
glutens
Homeostasis
Humans
immune tolerance
Immunological diseases
Immunological tolerance
Immunoregulation
Immunosuppression
Inflammatory diseases
Intestine
Lamina propria
Lymphocytes
Lymphocytes T
Peptides
Review
t-lymphocytes
T-Lymphocytes, Regulatory - immunology
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Summary:Celiac disease (CD) is a systemic immune-mediated disorder caused by the dietary gluten in individuals who are genetically susceptible to the disease. In fact, CD is a T cell-mediated immune disease in which gluten-derived peptides activate the lamina propria CD4+ Teff cells, and these T-cell subsets can cause the intestinal tissue damages. Also, there are additional subsets of CD4+ T cells with suppressor functions. These subsets express the master transcription factor, FOXP3, and include Tr1 cells and CD4+CD25+ regulatory T cells (Tregs), which are the main population involved in maintaining the peripheral tolerance, preventing the autoimmune diseases and limiting the chronic inflammatory diseases such as CD. The suppressive function of Tregs is important to maintain the immune homeostasis. This paper examined the features and the basic mechanisms used by Tregs to mediate the suppression in CD.
ISSN:1028-852X
2008-823X
DOI:10.29252/ibj.24.3.140