Gender modulates development of the metabolic syndrome phenotype in fructose-fed rats

We analyzed the effects of a fructose-rich diet (FRD) to test the assumption that the expression of metabolic syndrome phenotype is different in male and female rats. Two-way ANOVA revealed a significant effect of FRD on feeding behavior and carbohydrate/lipid metabolism. The increased caloric intak...

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Bibliographic Details
Published in:Archives of biological sciences 2013, Vol.65 (2), p.455-464
Main Authors: Koricanac, G., Djordjevic, Ana, Zakula, Zorica, Vojnovic-Milutinovic, Danijela, Tepavcevic, Snezana, Velickovic, Natasa, Milosavljevic, Tijana, Stojiljkovic, Mojca, Romic, Snjezana, Matic, Gordana
Format: Article
Language:English
Subjects:
blood pressure
Fructose rich diet
gender
glucose tolerance test
lipid metabolism
metabolic syndrome
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Summary:We analyzed the effects of a fructose-rich diet (FRD) to test the assumption that the expression of metabolic syndrome phenotype is different in male and female rats. Two-way ANOVA revealed a significant effect of FRD on feeding behavior and carbohydrate/lipid metabolism. The increased caloric intake in FRD rats of both sexes was followed by a cluster of gender-specific changes typical for the metabolic syndrome. Female rats were characterized by decreased glycemia, increased triglycerides, enlarged visceral adipose tissue and increased absolute mass of liver, without changes in systolic blood pressure and insulin sensitivity. In contrast, male rats developed less disturbances in physical and biochemical characteristics, but blood pressure and insulin sensitivity were impaired by FRD. The results emphasize the detrimental effects of fructose consumption on cardiovascular risk and insulin action in males, whereas females are affected by other metabolic disturbances. These results support the idea of gender-dependent differences in the expression of the metabolic syndrome phenotype.
ISSN:0354-4664
1821-4339
DOI:10.2298/ABS1302455K