Effect of age and estrogen on biochemical markers of bone turnover in postmenopausal women: a population-based study from Nepal

Osteoporosis, a common disease worldwide, is characterized by low bone mass and architectural deterioration of bone tissue, leading to enhanced bone fragility and increase in fracture risks. Both menopause and aging are related factors leading to greater risk of bone disease, particularly among post...

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Bibliographic Details
Published in:International journal of women's health 2017-01, Vol.9, p.781-788
Main Authors: Pardhe, Bashu Dev, Pathak, Sabala, Bhetwal, Anjeela, Ghimire, Sumitra, Shakya, Shreena, Khanal, Puspa Raj, Marahatta, Sujan Babu
Format: Article
Language:English
Subjects:
Age
Age (Biology)
Aging
Analysis
Biological markers
Body mass index
Bone density
Bone diseases
bone markers
Development and progression
estradiol
Estrogens
Fractures
Health aspects
Hormone replacement therapy
Laboratories
Menopause
Metabolism
Nepal
Original Research
Osteoporosis
Phosphatase
Physiological aspects
Population
Population-based studies
post menopause
Postmenopausal women
Questionnaires
Risk factors
Vitamin D
Womens health
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Summary:Osteoporosis, a common disease worldwide, is characterized by low bone mass and architectural deterioration of bone tissue, leading to enhanced bone fragility and increase in fracture risks. Both menopause and aging are related factors leading to greater risk of bone disease, particularly among postmenopausal women. Hence, the main purpose of this study was to investigate the differences in biochemical markers of bone turnover and to evaluate the association of hormones and age-related factors with biochemical markers between pre- and postmenopausal women. A descriptive cross-sectional study was conducted over a period of 6 months among the female population of Dholahity community, Lalitpur, Nepal. A total of 496 healthy women were selected based on the questionnaire strategy. Among them, 244 were premenopausal and 252 were postmenopausal women. Different bone markers were evaluated as per the guideline provided by the reagent manufacturer, and hormonal assay, particularly estradiol level assessment, was performed by chemiluminescence immunoassay-based technique. A significant decrease in serum calcium level and estradiol level was observed in postmenopausal women as compared to premenopausal women, whereas a significant increase in serum phosphorus and alkaline phosphatase (ALP) levels was seen among postmenopausal (
ISSN:1179-1411
1179-1411
DOI:10.2147/IJWH.S145191