Obstructive pulmonary disease in patients with previous tuberculosis: Pathophysiology of a community-based cohort

An association between chronic airflow limitation (CAL) and a history of pulmonary tuberculosis (PTB) has been confirmed in epidemiological studies, but the mechanisms responsible for this association are unclear. It is debated whether CAL in this context should be viewed as chronic obstructive pulm...

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Bibliographic Details
Published in:South African medical journal 2017-05, Vol.107 (5), p.440-445
Main Authors: Allwood, Brian W, Gillespie, Rencia, Galperin-Aizenberg, Maya, Bateman, Mary, Olckers, Helena, Taborda-Barata, Luis, Calligaro, Gregory L, Said-Hartley, Qonita, Van Zyl-Smit, Richard, Cooper, Christopher B, Van Rikxoort, Eva, Goldin, Jonathan, Beyers, Nulda, Bateman, Eric D
Format: Article
Language:English
Subjects:
Adults
Chronic airflow obstruction
Chronic obstructive pulmonary disease
Computed tomography
Lung function tests
Medicine
Phenotype
Physiology
Pulmonology
Radiology
South Africa
Tuberculosis
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Summary:An association between chronic airflow limitation (CAL) and a history of pulmonary tuberculosis (PTB) has been confirmed in epidemiological studies, but the mechanisms responsible for this association are unclear. It is debated whether CAL in this context should be viewed as chronic obstructive pulmonary disease (COPD) or a separate phenotype. To compare lung physiology and high-resolution computed tomography (HRCT) findings in subjects with CAL and evidence of previous (healed) PTB with those in subjects with smoking-related COPD without evidence of previous PTB. Subjects with CAL identified during a Burden of Obstructive Lung Disease (BOLD) study performed in South Africa were studied. Investigations included questionnaires, lung physiology (spirometry, body plethysmography and diffusing capacity) and quantitative HRCT scans to assess bronchial anatomy and the presence of emphysema (
ISSN:0256-9574
2078-5135
DOI:10.7196/SAMJ.2017.v107i5.12118