Effect of SMILE-derived decellularized lenticules as an adhesion barrier in a rabbit model of glaucoma filtration surgery

Background To investigate the effects of small incision lenticule extraction (SMILE)-derived decellularized lenticules on intraocular pressure (IOP) and conjunctival scarring in a rabbit model of glaucoma filtration surgery. Methods Trabeculectomy was performed on both eyes of New Zealand rabbits. A...

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Published in:BMC ophthalmology 2021-09, Vol.21 (1), p.1-329, Article 329
Main Authors: Yin, Houfa, Chen, Xinyi, Hong, Xiaogang, Ma, Jian, Wu, Fang, Wan, Ting, Sang, Yiwen, Fu, Qiuli, Qin, Zhenwei, Lyu, Danni, Wu, Wei, Yin, Jinfu, Yang, Yabo
Format: Article
Language:English
Subjects:
Adhesion
Adhesion barrier
Analysis
Conjunctiva
Cornea
Decellularized lenticule
Eye
Fibrosis
Filtration
Glaucoma
Neomycin
Ophthalmology
Rabbits
Reproducibility
Scars
SMILE
Surgery
Trabeculectomy
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Summary:Background To investigate the effects of small incision lenticule extraction (SMILE)-derived decellularized lenticules on intraocular pressure (IOP) and conjunctival scarring in a rabbit model of glaucoma filtration surgery. Methods Trabeculectomy was performed on both eyes of New Zealand rabbits. A decellularized lenticule was placed in the subconjunctival space in one eye of the rabbits (the decellularized lenticule group), and no adjunctive treatment was performed in the fellow eye (the control group). The filtering bleb features and IOP were evaluated 0, 3, 7, 14, 21, and 28 days after surgery, and histopathologic examination was performed 28 days after surgery. Results Decellularized lenticules significantly increased bleb survival and decreased IOP postoperatively in the rabbit model with no adverse side effects. The histopathologic results showed a larger subconjunctival space and less subconjunctival fibrosis in the decellularized lenticule group. Conclusions Decellularized lenticules can prevent postoperative conjunctiva-sclera adhesion and fibrosis, and they may represent a novel antifibrotic agent for trabeculectomy. Keywords: SMILE, Decellularized lenticule, Adhesion barrier, Glaucoma, Trabeculectomy
ISSN:1471-2415
1471-2415
DOI:10.1186/s12886-021-02090-3