MicroRNAs—The Heart of Post-Myocardial Infarction Remodeling

Myocardial infarction (MI) is one of the most frequent cardiac emergencies, with significant potential for mortality. One of the major challenges of the post-MI healing response is that replacement fibrosis could lead to left ventricular remodeling (LVR) and heart failure (HF). This process involves...

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Bibliographic Details
Published in:Diagnostics (Basel) 2021-09, Vol.11 (9), p.1675
Main Authors: Maries, Liana, Marian, Cătălin, Sosdean, Raluca, Goanta, Flavia, Sirbu, Ioan Ovidiu, Anghel, Andrei
Format: Article
Language:English
Subjects:
Apoptosis
biomarker
Biomarkers
Cardiomyocytes
Cardiovascular disease
Collagen
Connective tissue
Drug therapy
Families & family life
Fibroblasts
Gene expression
Genetic engineering
Growth factors
Heart attacks
Heart failure
Kinases
left ventricular remodeling
MicroRNAs
miRNA
Mortality
myocardial infarction
prognostic
Proteins
Review
Smooth muscle
Transcription factors
Tumor necrosis factor-TNF
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Summary:Myocardial infarction (MI) is one of the most frequent cardiac emergencies, with significant potential for mortality. One of the major challenges of the post-MI healing response is that replacement fibrosis could lead to left ventricular remodeling (LVR) and heart failure (HF). This process involves canonical and non-canonical transforming growth factor-beta (TGF-β) signaling pathways translating into an intricate activation of cardiac fibroblasts and disproportionate collagen synthesis. Accumulating evidence has indicated that microRNAs (miRNAs) significantly contribute to the modulation of these signaling pathways. This review summarizes the recent updates regarding the molecular mechanisms underlying the role of the over 30 miRNAs involved in post-MI LVR. In addition, we compare the contradictory roles of several multifunctional miRNAs and highlight their potential use in pressure overload and ischemia-induced fibrosis. Finally, we discuss their attractive role as prognostic biomarkers for HF, highlighting the most relevant human trials involving these miRNAs.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics11091675