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Clinical and prognostic aspects of patients with the Neuromyelitis Optica Spectrum Disorder (NMOSD) from a cohort in Northeast Brazil
Neuromyelitis optica spectrum disorders (NMOSD) is a rare inflammatory and demyelinating disease of the central nervous system (CNS) more frequent in women and Afro-descendants. No previous epidemiological or prognostic study has been conducted in the region of the state of Bahia, Brazilian Northeas...
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| Published in: | BMC neurology 2022-03, Vol.22 (1), p.95-95, Article 95 |
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| creator | Fukuda, Thiago Gonçalves Silva, Ivã Taiuan Fialho Dos Santos, Tayla Samanta Silva Filho, Marcos Baruch Portela de Abreu, Fernanda Ferreira Oliveira-Filho, Jamary |
| description | Neuromyelitis optica spectrum disorders (NMOSD) is a rare inflammatory and demyelinating disease of the central nervous system (CNS) more frequent in women and Afro-descendants. No previous epidemiological or prognostic study has been conducted in the region of the state of Bahia, Brazilian Northeast.
To evaluate clinical and prognostic aspects in patients with NMOSD from a cohort in northeastern Brazil.
A single-center retrospective study was conducted with consecutive patients diagnosed with NMOSD. Clinical and epidemiological characteristics were described. The degree of disability was expressed by the Expanded Disability Status Scale (EDSS). Worsening disability were analyzed through negative binomial regression adjusted for disease duration.
Ninety-one patients were included, 72 (79.1%) female and 67 (73.6%) afro descendants. Mean age at onset was 36 (± 14) years and 73.3% were anti-aquaporin-4 antibody positive. Isolated transverse myelitis (32.9%) and isolated optic neuritis (22.4%) were the most frequent initial clinical syndromes. After multivariate analysis, optic neuritis (RR = 0.45; 95% CI = 0.23 - 0.88; p = 0.020) and dyslipidemia (RR = 0.40; 95% CI = 0.20 - 0.83; p = 0.014) were associated with slower disease progression. Area postrema involvement (RR = 6.70; 95% CI = 3.31 - 13.54; p |
| doi_str_mv | 10.1186/s12883-022-02621-5 |
| format | article |
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To evaluate clinical and prognostic aspects in patients with NMOSD from a cohort in northeastern Brazil.
A single-center retrospective study was conducted with consecutive patients diagnosed with NMOSD. Clinical and epidemiological characteristics were described. The degree of disability was expressed by the Expanded Disability Status Scale (EDSS). Worsening disability were analyzed through negative binomial regression adjusted for disease duration.
Ninety-one patients were included, 72 (79.1%) female and 67 (73.6%) afro descendants. Mean age at onset was 36 (± 14) years and 73.3% were anti-aquaporin-4 antibody positive. Isolated transverse myelitis (32.9%) and isolated optic neuritis (22.4%) were the most frequent initial clinical syndromes. After multivariate analysis, optic neuritis (RR = 0.45; 95% CI = 0.23 - 0.88; p = 0.020) and dyslipidemia (RR = 0.40; 95% CI = 0.20 - 0.83; p = 0.014) were associated with slower disease progression. Area postrema involvement (RR = 6.70; 95% CI = 3.31 - 13.54; p < 0.001) and age at onset (RR = 1.03; 95% CI = 1.01 - 1.05; p = 0.003) were associated with faster disease progression.
In the first clinical and prognostic study in northeastern Brazil, we identified area postrema involvement, age at onset, optic neuritis at fist syndrome and dyslipidemia as the main prognostic factors associated with disease progression.</description><identifier>ISSN: 1471-2377</identifier><identifier>EISSN: 1471-2377</identifier><identifier>DOI: 10.1186/s12883-022-02621-5</identifier><identifier>PMID: 35296261</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adult ; Aquaporin 4 ; Brazil - epidemiology ; Brazilian Northeast ; Complications and side effects ; Demographic aspects ; Development and progression ; Diagnosis ; Dyslipidemias ; Female ; Health aspects ; Humans ; Male ; Middle Aged ; Neuromyelitis optica ; Neuromyelitis Optica - complications ; Neuromyelitis Optica - diagnosis ; Neuromyelitis Optica - epidemiology ; Neuromyelitis optica spectrum disorders ; Prognosis ; Prognostic factors ; Retrospective Studies ; Women ; Young Adult</subject><ispartof>BMC neurology, 2022-03, Vol.22 (1), p.95-95, Article 95</ispartof><rights>2022. The Author(s).</rights><rights>COPYRIGHT 2022 BioMed Central Ltd.</rights><rights>The Author(s) 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c535t-6aa2117c20d1a96b16e12cd72dd643c913cc956af8c50056c9465eae8d76f7d03</citedby><cites>FETCH-LOGICAL-c535t-6aa2117c20d1a96b16e12cd72dd643c913cc956af8c50056c9465eae8d76f7d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8925163/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8925163/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,37013,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35296261$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukuda, Thiago Gonçalves</creatorcontrib><creatorcontrib>Silva, Ivã Taiuan Fialho</creatorcontrib><creatorcontrib>Dos Santos, Tayla Samanta Silva</creatorcontrib><creatorcontrib>Filho, Marcos Baruch Portela</creatorcontrib><creatorcontrib>de Abreu, Fernanda Ferreira</creatorcontrib><creatorcontrib>Oliveira-Filho, Jamary</creatorcontrib><title>Clinical and prognostic aspects of patients with the Neuromyelitis Optica Spectrum Disorder (NMOSD) from a cohort in Northeast Brazil</title><title>BMC neurology</title><addtitle>BMC Neurol</addtitle><description>Neuromyelitis optica spectrum disorders (NMOSD) is a rare inflammatory and demyelinating disease of the central nervous system (CNS) more frequent in women and Afro-descendants. No previous epidemiological or prognostic study has been conducted in the region of the state of Bahia, Brazilian Northeast.
To evaluate clinical and prognostic aspects in patients with NMOSD from a cohort in northeastern Brazil.
A single-center retrospective study was conducted with consecutive patients diagnosed with NMOSD. Clinical and epidemiological characteristics were described. The degree of disability was expressed by the Expanded Disability Status Scale (EDSS). Worsening disability were analyzed through negative binomial regression adjusted for disease duration.
Ninety-one patients were included, 72 (79.1%) female and 67 (73.6%) afro descendants. Mean age at onset was 36 (± 14) years and 73.3% were anti-aquaporin-4 antibody positive. Isolated transverse myelitis (32.9%) and isolated optic neuritis (22.4%) were the most frequent initial clinical syndromes. After multivariate analysis, optic neuritis (RR = 0.45; 95% CI = 0.23 - 0.88; p = 0.020) and dyslipidemia (RR = 0.40; 95% CI = 0.20 - 0.83; p = 0.014) were associated with slower disease progression. Area postrema involvement (RR = 6.70; 95% CI = 3.31 - 13.54; p < 0.001) and age at onset (RR = 1.03; 95% CI = 1.01 - 1.05; p = 0.003) were associated with faster disease progression.
In the first clinical and prognostic study in northeastern Brazil, we identified area postrema involvement, age at onset, optic neuritis at fist syndrome and dyslipidemia as the main prognostic factors associated with disease progression.</description><subject>Adult</subject><subject>Aquaporin 4</subject><subject>Brazil - epidemiology</subject><subject>Brazilian Northeast</subject><subject>Complications and side effects</subject><subject>Demographic aspects</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Dyslipidemias</subject><subject>Female</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neuromyelitis optica</subject><subject>Neuromyelitis Optica - complications</subject><subject>Neuromyelitis Optica - diagnosis</subject><subject>Neuromyelitis Optica - epidemiology</subject><subject>Neuromyelitis optica spectrum disorders</subject><subject>Prognosis</subject><subject>Prognostic factors</subject><subject>Retrospective Studies</subject><subject>Women</subject><subject>Young Adult</subject><issn>1471-2377</issn><issn>1471-2377</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptUstu1DAUjRCIPuAHWCBLbMoixe84G6Qy5VGpzCwKa-vGdmZcJXFqZ0Dtnv_G05SqIyHLug-fc3SvdYriDcGnhCj5IRGqFCsxpflKSkrxrDgkvCIlZVX1_El-UByldI0xqRQnL4sDJmgtqSSHxZ9F5wdvoEMwWDTGsB5CmrxBkEZnpoRCi0aYvBty_ttPGzRtHFq6bQz9rev85BNajZkA6GpHiNsenfsUonURnSy_r67O36M2gxEgEzYhTsgPaJnjxkGa0KcId757VbxooUvu9UM8Ln5--fxj8a28XH29WJxdlkYwMZUSgBJSGYotgVo2RDpCja2otZIzUxNmTC0ktMoIjIU0NZfCgVO2km1lMTsuLmZdG-Baj9H3EG91AK_vGyGuNcS8TOe0UhwL2rhGtZwTpYAoSrlsc4UbcCxrfZy1xm3TO2vyD0Xo9kT3Xwa_0evwS6uaCiJ3AicPAjHcbF2adO-TcV0HgwvbpKnkmFFV1TxD383QNeTR_NCGrGh2cH0m61pwSthuu9P_oPKxrvcmDK71ub9HoDPBxJBSdO3j9ATrncX0bDGdLabvLaZFJr19uvcj5Z-n2F_4tMyg</recordid><startdate>20220316</startdate><enddate>20220316</enddate><creator>Fukuda, Thiago Gonçalves</creator><creator>Silva, Ivã Taiuan Fialho</creator><creator>Dos Santos, Tayla Samanta Silva</creator><creator>Filho, Marcos Baruch Portela</creator><creator>de Abreu, Fernanda Ferreira</creator><creator>Oliveira-Filho, Jamary</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20220316</creationdate><title>Clinical and prognostic aspects of patients with the Neuromyelitis Optica Spectrum Disorder (NMOSD) from a cohort in Northeast Brazil</title><author>Fukuda, Thiago Gonçalves ; Silva, Ivã Taiuan Fialho ; Dos Santos, Tayla Samanta Silva ; Filho, Marcos Baruch Portela ; de Abreu, Fernanda Ferreira ; Oliveira-Filho, Jamary</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c535t-6aa2117c20d1a96b16e12cd72dd643c913cc956af8c50056c9465eae8d76f7d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Aquaporin 4</topic><topic>Brazil - epidemiology</topic><topic>Brazilian Northeast</topic><topic>Complications and side effects</topic><topic>Demographic aspects</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Dyslipidemias</topic><topic>Female</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neuromyelitis optica</topic><topic>Neuromyelitis Optica - complications</topic><topic>Neuromyelitis Optica - diagnosis</topic><topic>Neuromyelitis Optica - epidemiology</topic><topic>Neuromyelitis optica spectrum disorders</topic><topic>Prognosis</topic><topic>Prognostic factors</topic><topic>Retrospective Studies</topic><topic>Women</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukuda, Thiago Gonçalves</creatorcontrib><creatorcontrib>Silva, Ivã Taiuan Fialho</creatorcontrib><creatorcontrib>Dos Santos, Tayla Samanta Silva</creatorcontrib><creatorcontrib>Filho, Marcos Baruch Portela</creatorcontrib><creatorcontrib>de Abreu, Fernanda Ferreira</creatorcontrib><creatorcontrib>Oliveira-Filho, Jamary</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>BMC neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukuda, Thiago Gonçalves</au><au>Silva, Ivã Taiuan Fialho</au><au>Dos Santos, Tayla Samanta Silva</au><au>Filho, Marcos Baruch Portela</au><au>de Abreu, Fernanda Ferreira</au><au>Oliveira-Filho, Jamary</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and prognostic aspects of patients with the Neuromyelitis Optica Spectrum Disorder (NMOSD) from a cohort in Northeast Brazil</atitle><jtitle>BMC neurology</jtitle><addtitle>BMC Neurol</addtitle><date>2022-03-16</date><risdate>2022</risdate><volume>22</volume><issue>1</issue><spage>95</spage><epage>95</epage><pages>95-95</pages><artnum>95</artnum><issn>1471-2377</issn><eissn>1471-2377</eissn><abstract>Neuromyelitis optica spectrum disorders (NMOSD) is a rare inflammatory and demyelinating disease of the central nervous system (CNS) more frequent in women and Afro-descendants. No previous epidemiological or prognostic study has been conducted in the region of the state of Bahia, Brazilian Northeast.
To evaluate clinical and prognostic aspects in patients with NMOSD from a cohort in northeastern Brazil.
A single-center retrospective study was conducted with consecutive patients diagnosed with NMOSD. Clinical and epidemiological characteristics were described. The degree of disability was expressed by the Expanded Disability Status Scale (EDSS). Worsening disability were analyzed through negative binomial regression adjusted for disease duration.
Ninety-one patients were included, 72 (79.1%) female and 67 (73.6%) afro descendants. Mean age at onset was 36 (± 14) years and 73.3% were anti-aquaporin-4 antibody positive. Isolated transverse myelitis (32.9%) and isolated optic neuritis (22.4%) were the most frequent initial clinical syndromes. After multivariate analysis, optic neuritis (RR = 0.45; 95% CI = 0.23 - 0.88; p = 0.020) and dyslipidemia (RR = 0.40; 95% CI = 0.20 - 0.83; p = 0.014) were associated with slower disease progression. Area postrema involvement (RR = 6.70; 95% CI = 3.31 - 13.54; p < 0.001) and age at onset (RR = 1.03; 95% CI = 1.01 - 1.05; p = 0.003) were associated with faster disease progression.
In the first clinical and prognostic study in northeastern Brazil, we identified area postrema involvement, age at onset, optic neuritis at fist syndrome and dyslipidemia as the main prognostic factors associated with disease progression.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>35296261</pmid><doi>10.1186/s12883-022-02621-5</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aquaporin 4 Brazil - epidemiology Brazilian Northeast Complications and side effects Demographic aspects Development and progression Diagnosis Dyslipidemias Female Health aspects Humans Male Middle Aged Neuromyelitis optica Neuromyelitis Optica - complications Neuromyelitis Optica - diagnosis Neuromyelitis Optica - epidemiology Neuromyelitis optica spectrum disorders Prognosis Prognostic factors Retrospective Studies Women Young Adult |
| title | Clinical and prognostic aspects of patients with the Neuromyelitis Optica Spectrum Disorder (NMOSD) from a cohort in Northeast Brazil |
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