Plasmacytoid dendritic cells in dermatology

Plasmacytoid dendritic cells are part of the dendritic cells family and are a relevant link between innate and adaptive immunity. They are the most potent producers of type 1 interferon, generating antiviral response, stimulating macrophages and dendritic cells and inducing activation and migration...

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Bibliographic Details
Published in:Anais brasileiros de dermatología 2021-01, Vol.96 (1), p.76-81
Main Authors: Dias de Oliveira, Natasha Favoretto, Santi, Claudia Giuli, Maruta, Celina Wakisaka, Aoki, Valeria
Format: Article
Language:English
Subjects:
Adaptive immunity
Dendritic Cells
Dermatological diseases
DERMATOLOGY
Humans
Immunity, Innate
Innate immunity
Interferon Type I
Review
T-Lymphocytes
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Summary:Plasmacytoid dendritic cells are part of the dendritic cells family and are a relevant link between innate and adaptive immunity. They are the most potent producers of type 1 interferon, generating antiviral response, stimulating macrophages and dendritic cells and inducing activation and migration of natural killer cells. Plasmacytoid dendritic cells also exert a role as antigen-presenting cells, promote T-lymphocyte responses, immunoregulation, plasma cells differentiation and antibody secretion. Even though plasmacytoid dendritic cells are not usually present in normal skin, their presence is detected in healing processes, viral infections, and inflammatory, autoimmune, and neoplastic diseases. In recent years, the presence of plasmacytoid dendritic cells in several dermatological diseases has been described, enhancing their potential role in the pathogenesis of such conditions. Future studies on the role of plasmacytoid dendritic cells in dermatology may lead to new therapeutic targets.
ISSN:0365-0596
1806-4841
1806-4841
DOI:10.1016/j.abd.2020.08.006