Tocilizumab in HIV patient with severe COVID-19: case report

A 73-year-old male patient who had a history of Human Immunodeficiency Virus (HIV) infection for over 20 years was diagnosed with SARS-CoV-2 infection. The patient was admitted to the Intensive Care Unit (ICU), where he remained for 25 days, due to a severe condition. Intubation, hemodialysis, and t...

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Bibliographic Details
Published in:AIDS research and therapy 2021-10, Vol.18 (1), p.73-73, Article 73
Main Authors: Bertozzi, Pedro Vieira, de Oliveira Vicente, Amanda, Pereira, Amanda Siqueira, de Sant'Ana, Joao Pedro Espinha, Mano, Rafaela Braga Cabrera, Jorge, Luciana Souza, da Silva Sardenberg, Rodrigo Afonso
Format: Article
Language:English
Subjects:
Aged
Analysis
Antibodies, Monoclonal, Humanized - therapeutic use
Antiretroviral agents
Care and treatment
Case Report
Case reports
Coinfection
Comorbidity
Coronaviruses
COVID-19
COVID-19 Drug Treatment
Diagnosis
Health aspects
Hemodialysis
Highly active antiretroviral therapy
HIV
HIV Infections - complications
HIV Infections - drug therapy
HIV patients
Homeostasis
Human immunodeficiency virus
Humans
Hypertension
Immune response
Immune system
Intubation
Lymphocytes
Male
Males
Monoclonal antibodies
Mortality
Patients
Recovery
Risk analysis
Risk factors
Ritonavir
Severe acute respiratory syndrome coronavirus 2
Tocilizumab
Tracheostomy
Viral diseases
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Summary:A 73-year-old male patient who had a history of Human Immunodeficiency Virus (HIV) infection for over 20 years was diagnosed with SARS-CoV-2 infection. The patient was admitted to the Intensive Care Unit (ICU), where he remained for 25 days, due to a severe condition. Intubation, hemodialysis, and tracheostomy were necessary to maintain homeostasis. In addition to regular treatment with etravirine, dolutegravir, darunavir, and ritonavir for highly active antiretroviral therapy, the patient received tocilizumab, which showed a great recovery in the patient's condition. The patient had several risk factors, such as male gender, age  >  70 years, and arterial hypertension. The use of tocilizumab was of great importance in the patient's recovery since the drug increased his immune response, which is deficient, due to HIV infection.
ISSN:1742-6405
1742-6405
DOI:10.1186/s12981-021-00404-5