Effects of resveratrol, grape juice or red wine consumption Irisin levels and fibronectin type III domain containing protein 5 and uncoupoling protein gene expression modulation in rats

The aim was investigate resveratrol, grape juice, or red wine effects on FNDC5 and UCP2 gene expression on muscle and adipose tissue of Wistar rats receiving a high-fat diet. Five groups of female Wistar rats formed with five animals in each (Control Group-CG, High-Fat Group-HFG-20%, Grape Juice Gro...

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Published in:Clinical Nutrition Experimental 2016-02, Vol.5 (C), p.1-5
Main Authors: de Souza Rocha, Gabrielle, da Silva Ferreira, Raiza, da Matta Alvarez Pimenta, Nina, Monteiro da Fonseca, Letícia, Mafra, Denise, Blondet, Vilma, de Souza da Fonseca, Adenilson, Girão Barroso, Sergio
Format: Article
Language:English
Subjects:
Gene expression
Grape juice
Irisin
Muscle tissue
Red wine
Resveratrol
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Summary:The aim was investigate resveratrol, grape juice, or red wine effects on FNDC5 and UCP2 gene expression on muscle and adipose tissue of Wistar rats receiving a high-fat diet. Five groups of female Wistar rats formed with five animals in each (Control Group-CG, High-Fat Group-HFG-20%, Grape Juice Group-GJG; Red Wine Group-RWG and Resveratrol Group-RG) were treated for 2 months. At the end, adipose and muscle tissues were collected, FNDC5 and UCP2 mRNA expressions were obtained by using real-time polymerase chain reaction. Irisin levels were assessed through ELISA. For comparison: two way ANOVA, using Duncan as post-test. FNDC5 mRNA expression was increased in RG and GJG muscle (p 
ISSN:2352-9393
2352-9393
DOI:10.1016/j.yclnex.2016.02.001