Effectiveness of Centchroman on Regression of Fibroadenosis and Mastalgia

• Published in: Journal of clinical and diagnostic research 2016-10, Vol.10 (10), p.PC10-PC14
• Main Authors: Rajswaroob, Udayakumar, Kannan, Rajendiran, Kannan, Narayanasamy Subbaraju, Tirouaroul, T
• Format: Article
• Language: English
• Subjects: cyclical; fibroadenoma; fibrocystic disease; hormonal therapy; non-cyclical; ormeloxifene
• ISSN: 2249-782X; 0973-709X
• DOI: 10.7860/JCDR/2016/20108.8604

Fibroadenosis and mastalgia are common among the women in reproductive age group. Treatment for these conditions is not yet standardised. Most of the drugs used for fibroadenosis and mastalgia are expensive and have side effects. To find out the efficacy of centchroman, a Selective Estrogens Receptor Modulator (SERM) on regression of fibroadenosis and mastalgia. Fifty one patients with mastalgia/fibroadenosis were treated with centchroman 30mg once daily on alternate days for a period of 3 months and followed up weekly for six months with Mastalgia chart and Visual Analog Scale (VAS) pain score. Before starting treatment, four patients presented with pain score of 6 followed by, 37 patients with a score of 4 and 10 patients with a score of 2. All the patients were started on tab centchroman 30mg OD alternate days and were reviewed on weekly basis with Mastalgia chart and VAS pain score for three months. On fifth and sixth visit, 46 patients reported with pain score 0, one with pain score of 2 and four with pain score of 6. The efficacy of centchroman was found to be significant (p-value = 0.001). Three patients (5.9%) reported epigastric pain and ten patients (19.6%) reported menstrual delay. A total of 38 patients did not complain of any side effect. Our study proves that centchroman is a safe and cost effective drug with significant efficacy on regression of fibroadenosis and mastalgia with minimal side effect.