Use of Microbiota to Fight Mosquito-Borne Disease

Mosquito-borne diseases cause more than 700 million people infected and one million people die (Caraballo and King, 2014). With the limitations of progress toward elimination imposed by insecticide- and drug-resistance, combined with the lack of vaccines, innovative strategies to fight mosquito-born...

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Bibliographic Details
Published in:Frontiers in genetics 2020-03, Vol.11, p.196-196
Main Authors: Huang, Wei, Wang, Sibao, Jacobs-Lorena, Marcelo
Format: Article
Language:English
Subjects:
arboviruses
Genetics
insect microbiota
malaria
mosquito-pathogen interactions
paratransgenesis
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Summary:Mosquito-borne diseases cause more than 700 million people infected and one million people die (Caraballo and King, 2014). With the limitations of progress toward elimination imposed by insecticide- and drug-resistance, combined with the lack of vaccines, innovative strategies to fight mosquito-borne disease are urgently needed. In recent years, the use of mosquito microbiota has shown great potential for cutting down transmission of mosquito-borne pathogens. Here we review what is known about the mosquito microbiota and how this knowledge is being used to develop new ways to control mosquito-borne disease. We also discuss the challenges for the eventual release of genetically modified (GM) symbionts in the field.
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2020.00196