A Promising, Novel Radiosensitizer Nanodrug Complex for Oral Cavity Cancer: Cetuximab and Cisplatin-Conjugated Gold Nanoparticles

Nanomedicine has provided promising tools for the imaging, diagnosis, and treatment of cancer. Gold nanoparticles (GNPs) may be useful in enhancing the efficacy of radiotherapy, such as radiosensitization, in cancer therapy. To develop a nanodrug complex containing cetuximab (C225,CTX) and cisplatin...

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Bibliographic Details
Published in:Balkan medical journal 2021-09, Vol.38 (5), p.278-286
Main Authors: Sürer, Şeniz İnanç, Elçitepe, Tarık Buğra, Akçay, Doğukan, Daşkın, Ezgi, Çalıbaşı Kocal, Gizem, Arıcan Alıcıkuş, Zümre, Eskiizmir, Görkem, Yapıcı, Kerim, Başbınar, Yasemin
Format: Article
Language:English
Subjects:
Cancer
Care and treatment
Cetuximab - pharmacology
Cetuximab - therapeutic use
Cisplatin
Cisplatin - pharmacology
Cisplatin - therapeutic use
Drug therapy
Gold
Health aspects
Humans
Metal Nanoparticles - therapeutic use
Mouth
Mouth cancer
Mouth Neoplasms - drug therapy
Mouth Neoplasms - pathology
Nanoparticles
Original
Pharmacology, Experimental
Radiation-Sensitizing Agents - pharmacology
Radiation-Sensitizing Agents - therapeutic use
Radiotherapy
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Summary:Nanomedicine has provided promising tools for the imaging, diagnosis, and treatment of cancer. Gold nanoparticles (GNPs) may be useful in enhancing the efficacy of radiotherapy, such as radiosensitization, in cancer therapy. To develop a nanodrug complex containing cetuximab (C225,CTX) and cisplatin (CDDP) conjugated with GNPs and to investigate its cytotoxic effects on oral cavity cancer cells when combined with radiotherapy. In vitro cell culture study. The GNPs were synthesized and successfully conjugated with cetuximab and cisplatin. Cell viability was monitored by the xCELLigence real-time cell analysis (RTCA) single-plate (SP) system in GNP-treated UPCI-SCC-131 cells for 48 hours. Cells with/without GNPs were irradiated with 6 MV X-rays, and colony formation was assayed to investigate the long-term effects of GNPs and the nanodrug complex after irradiation on radiotherapy-resistant oral cavity cancer cells. The GNPs entered the tumor cells, and GNP-CDDP (P
ISSN:2146-3123
2146-3131
DOI:10.5152/balkanmedj.2021.21013