The Involvement of Intestinal Tryptophan Metabolism in Inflammatory Bowel Disease Identified by a Meta-Analysis of the Transcriptome and a Systematic Review of the Metabolome

Evidence is emerging for the role of intestinal tryptophan metabolism in the development of inflammatory bowel disease (IBD). In order to identify the role of altered intestinal tryptophan metabolism in IBD pathogenesis, a meta-analysis of the transcriptome was performed to identify differentially e...

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Bibliographic Details
Published in:Nutrients 2023-06, Vol.15 (13), p.2886
Main Authors: Wang, Shan, van Schooten, Frederik-Jan, Jin, Han, Jonkers, Daisy, Godschalk, Roger
Format: Article
Language:English
Subjects:
Analysis
Biopsy
Crohn's disease
Datasets
Development and progression
Gastrointestinal diseases
Gene expression
Genes
Homeostasis
Humans
Inflammation
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory Bowel Diseases - genetics
Inflammatory Bowel Diseases - metabolism
Intestine
Intestines
Meta-analysis
Metabolism
Metabolites
Metabolome
Physiological aspects
Remission (Medicine)
Review
Serotonin
Systematic review
Transcriptome
Transcriptomes
Tryptophan
Tryptophan - metabolism
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Summary:Evidence is emerging for the role of intestinal tryptophan metabolism in the development of inflammatory bowel disease (IBD). In order to identify the role of altered intestinal tryptophan metabolism in IBD pathogenesis, a meta-analysis of the transcriptome was performed to identify differentially expressed genes involved in the tryptophan metabolism pathways in intestinal biopsies of IBD as compared to non-IBD controls. Moreover, a systematic review of the metabolome was performed to identify the concurrent changes in tryptophan metabolites. Integration of the transcriptome and metabolome identified various alterations in intestinal tryptophan metabolism during active disease in IBD patients, including decreased intestinal tryptophan absorption, enhanced kynurenine pathway, increased interstitial serotonin availability, changed indole pathway, and activated aryl hydrocarbon receptor signaling. Therefore, a network of intestinal tryptophan metabolism pathways in IBD could be established, helping to assess the potential of genes and metabolites involved in these pathways as diagnostic markers and targets for IBD management.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15132886