Effect of Allopregnanolone on Spatial Memory and Synaptic Proteins in Animal Model of Metabolic Syndrome

Metabolic Syndrome (MetS) is considered a common disorder, especially with a sedentary lifestyle and unhealthy food consumption. Cognitive impairment is one of the MetS consequences that worsens the quality of life of the patients. The study aimed to assess the therapeutic effect of the neurosteroid...

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Bibliographic Details
Published in:Brain sciences 2021-05, Vol.11 (5), p.644
Main Authors: Amin, Shaimaa Nasr, Abdalgeleel, Shaimaa Abdalaleem, Algahtany, Mubarak Ali, Shaltout, Sherif Ahmed, El Gazzar, Walaa Bayoumie, Elberry, Dalia Azmy
Format: Article
Language:English
Subjects:
allopregnanolone
Animal models
Animals
Biochemical markers
Blood pressure
Brain
Cognitive ability
Dietary minerals
Ethanol
Food consumption
GAP-43
GAP-43 protein
Gene expression
Glucose
Hippocampal plasticity
Hippocampus
Homeostasis
Hypertension
Insulin
Insulin resistance
Memory
Metabolic syndrome
Pregnanolone
Proteins
Quality of life
Software
Spatial memory
Synaptic plasticity
Synaptophysin
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Summary:Metabolic Syndrome (MetS) is considered a common disorder, especially with a sedentary lifestyle and unhealthy food consumption. Cognitive impairment is one of the MetS consequences that worsens the quality of life of the patients. The study aimed to assess the therapeutic effect of the neurosteroid Allopregnalonone on spatial memory and, therefore, the expression of two synaptic plasticity markers in the hippocampus. Thirty-two male rats were divided into four groups: control groups, MetS, and MetS + Allopregnalone. Spatial memory has been evaluated by the Y-maze task and blood pressure measured by the rat tail method. Biochemical evaluation of serum glucose, insulin, lipid profile, and hippocampal expression of Synaptophysin and Associated Protein 43 (GAP-43) were performed for assessing Allopregnanolone on serum and hippocampal markers. Allopregnanolone therapy improved working spatial memory, hypertension, and biochemical markers measured in the serum and hippocampus.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci11050644