Assessing biomarkers of remission in female patients with anorexia nervosa (REMANO): a protocol for a prospective cohort study with a nested case–control study using clinical, neurocognitive, biological, genetic, epigenetic and neuroimaging markers in a French specialised inpatient unit

BackgroundAnorexia nervosa (AN) is a severe psychiatric disorder associated with frequent relapses and variability in treatment responses. Previous literature suggested that such variability is influenced by premorbid vulnerabilities such as abnormalities of the reward system. Several factors may in...

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Bibliographic Details
Published in:BMJ open 2024-06, Vol.14 (6), p.e077260
Main Authors: Duriez, Philibert, Tolle, Virginie, Ramoz, Nicolas, Kimmel, Etienne, Charron, Sylvain, Viltart, Odile, Lebrun, Nicolas, Bienvenu, Thierry, Fadigas, Marie, Oppenheim, Catherine, Gorwood, Philip
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adult psychiatry
Anorexia
Anorexia Nervosa - blood
Anorexia Nervosa - genetics
Anorexia Nervosa - therapy
Biomarkers
Biomarkers - blood
Body Mass Index
Case-Control Studies
Cohort analysis
Dopamine
Eating disorders
Epigenetics
Female
Females
Food
France
Hospitalization
Humans
Investigations
Life Sciences
Magnetic resonance imaging
Mental disorders
Mental Health
Neuroimaging
Prospective Studies
Remission (Medicine)
Remission Induction
Young Adult
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Summary:BackgroundAnorexia nervosa (AN) is a severe psychiatric disorder associated with frequent relapses and variability in treatment responses. Previous literature suggested that such variability is influenced by premorbid vulnerabilities such as abnormalities of the reward system. Several factors may indicate these vulnerabilities, such as neurocognitive markers (tendency to favour delayed reward, poor cognitive flexibility, abnormal decision process), genetic and epigenetic markers, biological and hormonal markers, and physiological markers.The present study will aim to identify markers that can predict body mass index (BMI) stability 6 months after discharge. The secondary aim of this study will be focused on characterising the biological, genetic, epigenetic and neurocognitive markers of remission in AN.Methods and analysisOne hundred and twenty-five (n=125) female adult inpatients diagnosed with AN will be recruited and evaluated at three different times: at the beginning of hospitalisation, when discharged and 6 months later. Depending on the BMI at the third visit, patients will be split into two groups: stable remission (BMI≥18.5 kg/m²) or unstable remission (BMI
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2023-077260