Protective Effects of Hydroalcoholic Extract of Rosa canina Fruit on Vancomycin-Induced Nephrotoxicity in Rats

Vancomycin-induced nephrotoxicity (VIN) has been reported to occur in 5–35% of recipient patients. The aims of the study were to evaluate protective effects of Rosa canina (RC) on VIN in rats. Rats were randomly divided into five groups as follows: control group I, group II (received VAN 400 mg/kg/d...

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Bibliographic Details
Published in:Journal of toxicology 2021, Vol.2021, p.1-9
Main Authors: Sadeghi, Hossein, Karimizadeh, Ehsan, Sadeghi, Heibatollah, Panahi kokhdan, Esmaeel, Mansourian, Mahboubeh, Abbaszadeh-Goudarzi, Kazem, Shokripour, Mansoureh, Asfaram, Arash, Doustimotlagh, Amir Hossein
Format: Article
Language:English
Subjects:
Antibiotics
Antioxidants
Arthritis
Blood
Carbonyl compounds
Carbonyls
Chemical composition
Creatinine
Edema
Ethylenediaminetetraacetic acid
Kidneys
Laboratory animals
Lactose
Lipid peroxidation
Malondialdehyde
Medical research
Medicine, Experimental
Metabolites
Methicillin
Nitric oxide
Oral administration
Oxidative stress
Proteins
Rosa canina
Serum levels
Staphylococcus infections
Tissue analysis
Urea
Vancomycin
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Summary:Vancomycin-induced nephrotoxicity (VIN) has been reported to occur in 5–35% of recipient patients. The aims of the study were to evaluate protective effects of Rosa canina (RC) on VIN in rats. Rats were randomly divided into five groups as follows: control group I, group II (received VAN 400 mg/kg/day, every 12 h at doses of 200 mg/kg/day, for 7 consecutive days), group III (VAN + RC 250 mg/kg/day, for 7 consecutive days), group IV (VAN + RC 500 mg/kg/day, for consecutive days), and group V (received RC 500 mg/kg/day, for consecutive 7 days). On the eighth day after anesthetizing the animals, blood samples were taken from the heart, and then, the kidneys were removed to investigate kidney function, oxidative stress, and histopathological marker. Also, the chemical composition of RC extract was identified by GC-MS analysis. Oral dose of 500 mg/kg RC extract significantly reduced the serum levels of blood urea nitrogen (BUN), creatinine (Cr), malondialdehyde (MDA), and nitric oxide (NO) and also the kidney tissue MDA, protein carbonyl, and NO metabolites (nitrite) levels compared to the VAN-treated group (P
ISSN:1687-8191
1687-8205
DOI:10.1155/2021/5525714