Serum Copeptin in Cardiooncology Practice: Review of Pathophysiological and Clinical Implications

In cardiooncology practice, "early cardiotoxicity" refers to an emerging subclinical myocardial dysfunction/injury in response to certain chemotherapeutic regimens. This condition can progress to overt cardiotoxicity in time and hence warrants proper and timely diagnostic and preventive st...

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Bibliographic Details
Published in:Balkan medical journal 2023-03, Vol.40 (2), p.82-92
Main Authors: Yalta, Kenan, Yetkin, Ertan, Yalta, Tülin
Format: Article
Language:English
Subjects:
Antineoplastic Agents - adverse effects
Antineoplastic Agents - therapeutic use
Arginine
Biomarkers - blood
Cancer
Cardiotoxicity - blood
Cardiotoxicity - diagnosis
Cardiotoxicity - etiology
Cardiovascular diseases
Chemotherapy
Complications and side effects
Development and progression
Diagnosis
Echocardiography
Glycopeptides - blood
Health aspects
Heart Injuries - blood
Heart Injuries - chemically induced
Heart Injuries - diagnosis
Humans
Invited Review
Neoplasms - blood
Neoplasms - drug therapy
Physiological aspects
Risk factors
Vasopressin
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Summary:In cardiooncology practice, "early cardiotoxicity" refers to an emerging subclinical myocardial dysfunction/injury in response to certain chemotherapeutic regimens. This condition can progress to overt cardiotoxicity in time and hence warrants proper and timely diagnostic and preventive strategies. Current diagnostic strategies for "early cardiotoxicity" are largely based on conventional biomarkers and certain echocardiographic indices. However, a significant gap still exists in this setting, warranting further strategies to improve diagnosis and overall prognosis in cancer survivors. Copeptin (surrogate marker of the arginine vasopressine axis) might serve as a promising adjunctive guide for the timely detection, risk stratification, and management of early cardiotoxicity on top of conventional strategies largely due to its multifaceted pathophysiological implications in the clinical setting. This work aims to focus on serum copeptin as a marker of "early cardiotoxicity" and its general clinical implications in patients with cancer.
ISSN:2146-3123
2146-3131
DOI:10.4274/balkanmedj.galenos.2023.2023-2-14