Relationship between progression of visual field defect and intraocular pressure in primary open-angle glaucoma

• Published in: Clinical ophthalmology (Auckland, N.Z.) N.Z.), 2015-01, Vol.9 (default), p.1373-1378
• Main Authors: Naito, Tomoko, Yoshikawa, Keiji, Mizoue, Shiro, Nanno, Mami, Kimura, Tairo, Suzumura, Hirotaka, Shiraga, Fumio
• Format: Article
• Language: English
• Subjects: Analysis; Care and treatment; Collaboration; Comparative analysis; Defects; Development and progression; Field study; Glaucoma; Hypertension; Intraocular pressure; MD slope; Measurement; Myopia; normal-tension glaucoma; Open-angle glaucoma; Original Research; primary open-angle glaucoma; progression of visual field defects; Standard deviation; Visual acuity
• ISSN: 1177-5467; 1177-5483; 1177-5483
• DOI: 10.2147/opth.s86450

To analyze the relationship between intraocular pressure (IOP) and the progression of visual field defects in Japanese primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG) patients. The subjects of the study were patients undergoing treatment for POAG or NTG who had performed visual field tests at least ten times with a Humphrey field analyzer (Swedish interactive thresholding algorithm standard, C30-2 program). The progression of visual field defects was defined by a significantly negative value of the mean deviation slope at the final visual field test during the follow-up period. The relationships between the progression of visual field defects and IOP, as well as other clinical factors, were retrospectively analyzed. A total of 156 eyes of 156 patients were included in the analysis. Significant progression of visual field defects was observed in 70 eyes of 70 patients (44.9%), while no significant progression was evident in 86 eyes of 86 patients (55.1%). The eyes with visual field defect progression had significantly lower baseline IOP (P