Angucycline Glycosides from an Intertidal Sediments Strain Streptomyces sp. and Their Cytotoxic Activity against Hepatoma Carcinoma Cells

Four angucycline glycosides including three new compounds landomycin N ( ), galtamycin C ( ) and vineomycin D ( ), and a known homologue saquayamycin B ( ), along with two alkaloids 1-acetyl-β-carboline ( ) and indole-3-acetic acid ( ), were isolated from the fermentation broth of an intertidal sedi...

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Bibliographic Details
Published in:Marine drugs 2018-11, Vol.16 (12), p.470
Main Authors: Peng, Aihong, Qu, Xinying, Liu, Fangyuan, Li, Xia, Li, Erwei, Xie, Weidong
Format: Article
Language:English
Subjects:
Acetic acid
angucycline glycosides
Apoptosis
Carbon
Cells
Chromatography
Cytotoxicity
Doxorubicin
Fermentation
Glycosides
Hepatoma
Homology
Indoleacetic acid
Liver cancer
Neoplasms
NMR
Nuclear magnetic resonance
Physical characteristics
saquayamycin
Sediment
Sediments
SMMC-7721
Streptomyces
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Summary:Four angucycline glycosides including three new compounds landomycin N ( ), galtamycin C ( ) and vineomycin D ( ), and a known homologue saquayamycin B ( ), along with two alkaloids 1-acetyl-β-carboline ( ) and indole-3-acetic acid ( ), were isolated from the fermentation broth of an intertidal sediments-derived sp. Their structures were established by IR, HR-ESI-MS, 1D and 2D NMR techniques. Among the isolated angucyclines, saquayamycin B ( ) displayed potent cytotoxic activity against hepatoma carcinoma cells HepG-2, SMMC-7721 and plc-prf-5, with IC values 0.135, 0.033 and 0.244 μM respectively, superior to doxorubicin. Saquayamycin B ( ) also induced apoptosis in SMMC-7721 cells as detected by its morphological characteristics in 4',6-diamidino-2-phenylindole (DAPI) staining experiment.
ISSN:1660-3397
1660-3397
DOI:10.3390/md16120470