Review and Perspectives on the Structure–Function Relationships of the Gag Subunits of Feline Immunodeficiency Virus

The Gag polyprotein is implied in the budding as well as the establishment of the supramolecular architecture of infectious retroviral particles. It is also involved in the early phases of the replication of retroviruses by protecting and transporting the viral genome towards the nucleus of the infe...

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Published in:Pathogens (Basel) 2021-11, Vol.10 (11), p.1502
Main Authors: Long, Mathieu, Toesca, Johan, Guillon, Christophe
Format: Article
Language:English
Subjects:
Animals
Basic Medicine
Biochemistry, Molecular Biology
Biologi
Biological Sciences
Capsid
Domestic animals
Endangered species
Feline Immunodeficiency Virus
FIV
Gag
Gag protein
Genomes
HIV
Human Immunodeficiency Virus
Immune system
Late domain
Life Sciences
Matrix
Medical and Health Sciences
Medicin och hälsovetenskap
Medicinska och farmaceutiska grundvetenskaper
Microbiology
Microbiology and Parasitology
Microbiology in the medical area
Mikrobiologi
Mikrobiologi inom det medicinska området
Natural Sciences
Naturvetenskap
Nucleocapsid
Plasma
Proteins
Review
Structural Biology
Structure
Structure-function relationships
Virology
Viruses
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description The Gag polyprotein is implied in the budding as well as the establishment of the supramolecular architecture of infectious retroviral particles. It is also involved in the early phases of the replication of retroviruses by protecting and transporting the viral genome towards the nucleus of the infected cell until its integration in the host genome. Therefore, understanding the structure–function relationships of the Gag subunits is crucial as each of them can represent a therapeutic target. Though the field has been explored for some time in the area of Human Immunodeficiency Virus (HIV), it is only in the last decade that structural data on Feline Immunodeficiency Virus (FIV) Gag subunits have emerged. As FIV is an important veterinary issue, both in domestic cats and endangered feline species, such data are of prime importance for the development of anti-FIV molecules targeting Gag. This review will focus on the recent advances and perspectives on the structure–function relationships of each subunit of the FIV Gag polyprotein.
doi_str_mv 10.3390/pathogens10111502
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subjects Animals
Basic Medicine
Biochemistry, Molecular Biology
Biologi
Biological Sciences
Capsid
Domestic animals
Endangered species
Feline Immunodeficiency Virus
FIV
Gag
Gag protein
Genomes
HIV
Human Immunodeficiency Virus
Immune system
Late domain
Life Sciences
Matrix
Medical and Health Sciences
Medicin och hälsovetenskap
Medicinska och farmaceutiska grundvetenskaper
Microbiology
Microbiology and Parasitology
Microbiology in the medical area
Mikrobiologi
Mikrobiologi inom det medicinska området
Natural Sciences
Naturvetenskap
Nucleocapsid
Plasma
Proteins
Review
Structural Biology
Structure
Structure-function relationships
Virology
Viruses
title Review and Perspectives on the Structure–Function Relationships of the Gag Subunits of Feline Immunodeficiency Virus
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