Racial Differences in Circulating Natriuretic Peptide Levels: The Atherosclerosis Risk in Communities Study

Background Natriuretic peptides promote natriuresis, diuresis, and vasodilation. Experimental deficiency of natriuretic peptides leads to hypertension (HTN) and cardiac hypertrophy, conditions more common among African Americans. Hospital‐based studies suggest that African Americans may have reduced...

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Bibliographic Details
Published in:Journal of the American Heart Association 2015-05, Vol.4 (5), p.n/a
Main Authors: Gupta, Deepak K., Claggett, Brian, Wells, Quinn, Cheng, Susan, Li, Man, Maruthur, Nisa, Selvin, Elizabeth, Coresh, Josef, Konety, Suma, Butler, Kenneth R., Mosley, Thomas, Boerwinkle, Eric, Hoogeveen, Ron, Ballantyne, Christie M., Solomon, Scott D.
Format: Article
Language:English
Subjects:
African Americans - ethnology
African Americans - genetics
ancestry informative markers
Atherosclerosis - epidemiology
Atherosclerosis - ethnology
Atherosclerosis - genetics
deficiency
European Continental Ancestry Group - ethnology
European Continental Ancestry Group - genetics
Female
Humans
hypertension
Hypertension - epidemiology
Hypertension - ethnology
Hypertension - genetics
Male
Middle Aged
natriuretic peptide
Natriuretic Peptide, Brain - blood
Original Research
Peptide Fragments - blood
race
Residence Characteristics - statistics & numerical data
Risk Factors
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Summary:Background Natriuretic peptides promote natriuresis, diuresis, and vasodilation. Experimental deficiency of natriuretic peptides leads to hypertension (HTN) and cardiac hypertrophy, conditions more common among African Americans. Hospital‐based studies suggest that African Americans may have reduced circulating natriuretic peptides, as compared to Caucasians, but definitive data from community‐based cohorts are lacking. Methods and Results We examined plasma N‐terminal pro B‐type natriuretic peptide (NTproBNP) levels according to race in 9137 Atherosclerosis Risk in Communities (ARIC) Study participants (22% African American) without prevalent cardiovascular disease at visit 4 (1996–1998). Multivariable linear and logistic regression analyses were performed adjusting for clinical covariates. Among African Americans, percent European ancestry was determined from genetic ancestry informative markers and then examined in relation to NTproBNP levels in multivariable linear regression analysis. NTproBNP levels were significantly lower in African Americans (median, 43 pg/mL; interquartile range [IQR], 18, 88) than Caucasians (median, 68 pg/mL; IQR, 36, 124; P
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.115.001831