Evaluation of efficacy of pilocarpine and bethanechol in xerostomic denture wearers

• Published in: Journal of pharmacy & bioallied science 2020-08, Vol.12 (5), p.378-381
• Main Authors: Singh, Revati, Singh, Rohit, Singh, Supriya, Sinha, Rani, Kulkarni, Ganesh, Jois, Harshvardhan
• Format: Article
• Language: English
• Subjects: Analysis; bethanechol; Cevimeline; Dentures; Original; Pilocarpine; Saliva; Secretions; sialagogue; Xerostomia
• ISSN: 0975-7406; 0976-4879; 0975-7406
• DOI: 10.4103/jpbs.JPBS_111_20

Aim: The aim of this study was to evaluate effectiveness of bethanechol and pilocarpine among xerostomic denture wearers. Materials and Methods: This in vitro study was conducted in 60 complete denture wearers of both genders. For assessment of salivary flow, resting saliva and stimulated saliva were collected. Patients were split into two groups consisting of 30 patients each. Pilocarpine was given to patients in group I and patients in group II received bethanechol. Salivary flow was measured at baseline, after 2 weeks, and after 4 weeks. Results: The mean whole resting saliva in patients of group I was 0.61 mg/mL and in that of group II was 0.65 mg/mL. The mean whole stimulated saliva in patients of group I was 1.35 mg/mL and in group II it was 1.51 mg/mL. The mean whole resting saliva after 2 weeks in patients of group I was 0.83 mg/mL and in group II was 0.92 mg/mL. Whole stimulated saliva in patients of group I was 1.67 mg/mL, and in patients of group II it was 1.86 mg/mL. The difference noted was significant (P < 0.05). The mean whole resting saliva after 4 weeks in patients of group I was 1.23 mg/mL and in that of group II was 1.43 mg/mL. Whole stimulated saliva in patients of group I was 1.98 mg/mL and in patients of group II it was 2.04 mg/mL. Conclusion: Authors found that both agents were effective in increasing salivary secretions. However, pilocarpine is a more effective sialagogue as compared to bethanechol in completely edentulous patients with xerostomia.