Effects of eugenol on pain response to the formalin test and plasma antioxidant activity in high fructose drinking water in male rats

Background: Increased consumption of fructose in recent years has increased the risk of developing metabolic syndrome. In this syndrome, induction of oxidative stress, cellular dysfunction, and decrease of antioxidant capacity can change response to pain. Therefore, this study aims to investigate th...

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Bibliographic Details
Published in:International journal of preventive medicine 2019-01, Vol.10 (1), p.151-151
Main Authors: Ghofran, Omid, Safari, Tahereh, Shahraki, Mohammad
Format: Article
Language:English
Subjects:
Analgesics
Antioxidants
Antioxidants (Nutrients)
Care and treatment
Diabetes
Dosage and administration
Drinking water
Eugenol
Experiments
Formaldehyde
Fructose
Health aspects
Insulin
Insulin resistance
Malondialdehyde
Metabolic disorders
Metabolic syndrome
Metabolic syndrome X
Metabolites
Methods
Monosaccharides
Obesity
Original
Oxidative stress
Pain
Pain management
pain measurement
Pain perception
Phenols (Class of compounds)
Physiological aspects
Water
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Summary:Background: Increased consumption of fructose in recent years has increased the risk of developing metabolic syndrome. In this syndrome, induction of oxidative stress, cellular dysfunction, and decrease of antioxidant capacity can change response to pain. Therefore, this study aims to investigate the antinociceptive and antioxidant effects of eugenol on metabolic syndrome induced by a fructose-rich diet in rats. Methods: The rats were randomly assigned to five groups, to be under experiment for eight weeks. The first, control group, the second fructose 10% plus tween 0.5% (Fr + veh), the third fructose 10% (Fr), and the fourth fructose 10% plus a single dose of eugenol 100 mg/kg (Fr + EoS). However, the fifth obtained fructose 10% plus a continuous dose of eugenol 20 mg/kg/day (Fr + EoC) for the last 10 days of the experiment. After formalin test, blood samples were taken from the animals' hearts followed by analysis for biochemical factors. Results: This study shows that fructose administration does not change any pain response and there are not any changes in pain response between Fr group and control group. However, treatment with single and continuous dose of eugenol in Fr + EoS and Fr + EoC groups significantly decreases response to pain in the first and second phase of formalin test in comparison with Fr group (P
ISSN:2008-7802
2008-8213
DOI:10.4103/ijpvm.IJPVM_348_17