Altered Functional Connectivity Strength at Rest in Medication-Free Obsessive-Compulsive Disorder

Background. Previous studies explored the whole-brain functional connectome using the degree approach in patients with obsessive-compulsive disorder (OCD). However, whether the altered degree values can be used to discriminate OCD from healthy controls (HCs) remains unclear. Methods. A total of 40 m...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neural transplantation & plasticity 2021-09, Vol.2021, p.3741104-9
Main Authors: Lv, Dan, Ou, Yangpan, Wang, Yuhua, Ma, Jidong, Zhan, Chuang, Yang, Ru, Chen, Yunhui, Shang, Tinghuizi, Jia, Cuicui, Sun, Lei, Zhang, Guangfeng, Sun, Zhenghai, Li, Jinyang, Wang, Xiaoping, Guo, Wenbin, Li, Ping
Format: Article
Language:English
Subjects:
Adult
Alzheimer's disease
Anxiety
Brain
Brain - diagnostic imaging
Brain - physiopathology
Brain research
Cognition & reasoning
Drug therapy
Education
Female
Humans
Magnetic Resonance Imaging - methods
Male
Medical imaging
Mental depression
Nerve Net - diagnostic imaging
Nerve Net - physiopathology
Neuroses
Obsessive compulsive disorder
Obsessive-Compulsive Disorder - diagnostic imaging
Obsessive-Compulsive Disorder - physiopathology
Rest - physiology
Schizophrenia
Somatotropin
Support vector machines
Time series
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background. Previous studies explored the whole-brain functional connectome using the degree approach in patients with obsessive-compulsive disorder (OCD). However, whether the altered degree values can be used to discriminate OCD from healthy controls (HCs) remains unclear. Methods. A total of 40 medication-free patients with OCD and 38 HCs underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan. Data were analyzed with the degree approach and a support vector machine (SVM) classifier. Results. Patients with OCD showed increased degree values in the left thalamus and left cerebellum Crus I and decreased degree values in the left dorsolateral prefrontal cortex, right precuneus, and left postcentral gyrus. SVM classification analysis indicated that the increased degree value in the left thalamus is a marker of OCD, with an acceptable accuracy of 88.46%, sensitivity of 87.50%, and specificity of 89.47%. Conclusion. Altered degree values within and outside the cortical-striatal-thalamic-cortical (CSTC) circuit may cocontribute to the pathophysiology of OCD. Increased degree values of the left thalamus can be used as a future marker for OCD understanding-classification.
ISSN:2090-5904
0792-8483
1687-5443
DOI:10.1155/2021/3741104