Simvastatin versus Calcium Hydroxide Direct Pulp Capping of Human Primary Molars: A Randomized Clinical Trial

The aim of present study was to investigate pulp-dentin complex reactions following direct pulp capping (DPC) with calcium hydroxide [Ca(OH)2] and simvastatin as pulp-capping materials in the primary human molars. 120 primary molar teeth which had to be extracted for orthodontic reasons were randoml...

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Published in:Journal of dental research, dental clinics, dental prospects dental clinics, dental prospects, 2013-01, Vol.7 (1), p.8-14
Main Authors: Asl Aminabadi, Naser, Maljaei, Ensiyeh, Erfanparast, Leila, Ala Aghbali, Amir, Hamishehkar, Hamed, Najafpour, Ebrahim
Format: Article
Language:English
Subjects:
Calcium
Calcium hydroxide
Clinical trials
Cytotoxicity
Dentin
Dentistry
direct pulp capping
Drug dosages
Gangrene
Gene expression
hard tissue formation
inflammation
Mineralization
Original
Orthodontics
Pediatrics
simvastatin
Studies
Success
Teeth
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container_title Journal of dental research, dental clinics, dental prospects
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Maljaei, Ensiyeh
Erfanparast, Leila
Ala Aghbali, Amir
Hamishehkar, Hamed
Najafpour, Ebrahim
description The aim of present study was to investigate pulp-dentin complex reactions following direct pulp capping (DPC) with calcium hydroxide [Ca(OH)2] and simvastatin as pulp-capping materials in the primary human molars. 120 primary molar teeth which had to be extracted for orthodontic reasons were randomly allocated into four groups. Group Ι as a control, underwent DPC with calcium hydroxide. The dental pulp in group ІІ, ІІІ and ІV were directly capped with simvastatin-based materials at concentrations of 1, 5 and 10 µM, respectively. All of the teeth were restored with stainless steel crown. After a mean period of 7.41 months teeth were extracted and processed for histological examination and categorized in terms of hard tissue formation and pulp inflammation. Teeth in group I had statistically favorable outcomes in hard tissue formation and pulp inflammation than did the groups ІІ, ІІІ and ІV (P < 0.001). Considering three different concentrations of simvastatin, the result showed a dose dependent trend. Teeth in group ІV showed significantly lower rates of hard tissue formation and higher rates of pulp inflammation and necrosis compared to those of groups ІІ (P < 0.05). The findings of this study depicted that healing with no inflammation and hard tissue formation following statin treatment occurs with a lower rate than that with the calcium hydroxide.
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Group Ι as a control, underwent DPC with calcium hydroxide. The dental pulp in group ІІ, ІІІ and ІV were directly capped with simvastatin-based materials at concentrations of 1, 5 and 10 µM, respectively. All of the teeth were restored with stainless steel crown. After a mean period of 7.41 months teeth were extracted and processed for histological examination and categorized in terms of hard tissue formation and pulp inflammation. Teeth in group I had statistically favorable outcomes in hard tissue formation and pulp inflammation than did the groups ІІ, ІІІ and ІV (P &lt; 0.001). Considering three different concentrations of simvastatin, the result showed a dose dependent trend. Teeth in group ІV showed significantly lower rates of hard tissue formation and higher rates of pulp inflammation and necrosis compared to those of groups ІІ (P &lt; 0.05). 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source Publicly Available Content Database; PubMed Central
subjects Calcium
Calcium hydroxide
Clinical trials
Cytotoxicity
Dentin
Dentistry
direct pulp capping
Drug dosages
Gangrene
Gene expression
hard tissue formation
inflammation
Mineralization
Original
Orthodontics
Pediatrics
simvastatin
Studies
Success
Teeth
title Simvastatin versus Calcium Hydroxide Direct Pulp Capping of Human Primary Molars: A Randomized Clinical Trial
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