U-Shaped Relationship of Non-HDL Cholesterol With All-Cause and Cardiovascular Mortality in Men Without Statin Therapy

BackgroundNon-HDL-C is well established causal risk factor for the progression of atherosclerotic cardiovascular disease. However, there remains a controversial pattern of how non-HDL-C relates to all-cause and cardiovascular mortality, and the concentration of non-HDL-C where the risk of mortality...

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Bibliographic Details
Published in:Frontiers in cardiovascular medicine 2022-07, Vol.9, p.903481-903481
Main Authors: Zeng, Rui-Xiang, Xu, Jun-Peng, Kong, Yong-Jie, Tan, Jia-Wei, Guo, Li-Heng, Zhang, Min-Zhou
Format: Article
Language:English
Subjects:
all-cause mortality
Cardiovascular Medicine
cardiovascular mortality
men
non-HDL cholesterol
U-shaped relationship
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Summary:BackgroundNon-HDL-C is well established causal risk factor for the progression of atherosclerotic cardiovascular disease. However, there remains a controversial pattern of how non-HDL-C relates to all-cause and cardiovascular mortality, and the concentration of non-HDL-C where the risk of mortality is lowest is not defined. MethodsA population-based cohort study using data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2014. Male participants without statin therapy were divided into the six groups according to non-HDL-C levels (
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2022.903481