Low-Density Lipoproteins Oxidation and Endometriosis

The etiopathogenesis of endometriosis still remains unknown. Recent data provide new valuable information concerning the role of oxidative stress in the pathophysiology of the disease. It has been proved that levels of different lipid peroxidation end products are increased in both peritoneal fluid...

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Bibliographic Details
Published in:Mediators of Inflammation 2013-01, Vol.2013 (2013), p.134-137-216
Main Authors: Polak, Grzegorz, Barczyński, Bartłomiej, Kwaśniewski, Wojciech, Bednarek, Wiesława, Wertel, Iwona, Derewianka-Polak, Magdalena, Kotarski, Jan
Format: Article
Language:English
Subjects:
Adolescent
Adult
Ascitic Fluid - metabolism
Development and progression
Disease Progression
Endometriosis
Endometriosis - metabolism
Endometriosis - pathology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Laparoscopy
Lipid Peroxidation
Lipid research
Lipoproteins, LDL - metabolism
Low density lipoproteins
Middle Aged
Ovarian Cysts - metabolism
Ovarian Cysts - pathology
Oxidative Stress
Oxygen - chemistry
Properties
Young Adult
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Summary:The etiopathogenesis of endometriosis still remains unknown. Recent data provide new valuable information concerning the role of oxidative stress in the pathophysiology of the disease. It has been proved that levels of different lipid peroxidation end products are increased in both peritoneal fluid (PF) and serum of endometriotic patients. We assessed the concentration of oxidized low-density lipoproteins (oxLDL) in PF of 110 women with different stages of endometriosis and 119 women with serous (n=78) or dermoid (n=41) ovarian cysts, as the reference groups. PF oxLDL levels were evaluated by ELISA. We found that concentrations of oxLDL in PF of endometriotic women were significantly higher compared to women with serous but not dermoid ovarian cysts. Interestingly, by analyzing concentrations of oxLDL in women with different stages of the disease, it was noted that they are significantly higher only in the subgroup of patients with stage IV endometriosis as compared to women with ovarian serous cysts. In case of minimal, mild, and moderate disease, PF oxLDL levels were similar to those noted in reference groups. Our results indicate that disrupted oxidative status in the peritoneal cavity of women with endometriosis may play a role in the pathogenesis of advanced stages of the disease.
ISSN:0962-9351
1466-1861
DOI:10.1155/2013/624540