Current Progress in Magnetic Resonance-Guided Focused Ultrasound to Facilitate Drug Delivery across the Blood-Brain Barrier

This review discusses the current progress in the clinical use of magnetic resonance-guided focused ultrasound (MRgFUS) and other ultrasound platforms to transiently permeabilize the blood-brain barrier (BBB) for drug delivery in neurological disorders and neuro-oncology. Safety trials in humans hav...

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Bibliographic Details
Published in:Pharmaceutics 2024-05, Vol.16 (6), p.719
Main Authors: Meng, Ying, Kalia, Lorraine V, Kalia, Suneil K, Hamani, Clement, Huang, Yuexi, Hynynen, Kullervo, Lipsman, Nir, Davidson, Benjamin
Format: Article
Language:English
Subjects:
Alzheimer’s disease
Blood vessels
Blood-brain barrier
Cavitation
Clinical trials
Disease
Drug delivery systems
focused ultrasound
glioma
Monoclonal antibodies
MRgFUS
Parkinson’s disease
Review
Surgery
Ultrasonic imaging
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Summary:This review discusses the current progress in the clinical use of magnetic resonance-guided focused ultrasound (MRgFUS) and other ultrasound platforms to transiently permeabilize the blood-brain barrier (BBB) for drug delivery in neurological disorders and neuro-oncology. Safety trials in humans have followed on from extensive pre-clinical studies, demonstrating a reassuring safety profile and paving the way for numerous translational clinical trials in Alzheimer's disease, Parkinson's disease, and primary and metastatic brain tumors. Future directions include improving ultrasound delivery devices, exploring alternative delivery approaches such as nanodroplets, and expanding the application to other neurological conditions.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics16060719