Interleukin-6 in systemic sclerosis and potential correlation with pulmonary involvement

A progressive pulmonary involvement is frequent in systemic sclerosis and it is the leading cause of morbidity and mortality. IL-6 has been implicated in the pathogenesis of systemic sclerosis via stimulation of fibroblasts to produce excess collagen and glycosaminoglycan. Specific correlation betwe...

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Bibliographic Details
Published in:The Egyptian journal of chest diseases and tuberculosis 2015-01, Vol.64 (1), p.237-241
Main Authors: Yousif, Maha, Habib, Rehab, Esaely, Heba, Yasin, Rabab, Sonbol, Ahmed
Format: Article
Language:English
Subjects:
Cytokines
High resolution CT
Interleukin-6
Interstitial lung disease
Systemic sclerosis
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Summary:A progressive pulmonary involvement is frequent in systemic sclerosis and it is the leading cause of morbidity and mortality. IL-6 has been implicated in the pathogenesis of systemic sclerosis via stimulation of fibroblasts to produce excess collagen and glycosaminoglycan. Specific correlation between IL-6 and lung involvement have not been found yet. To study the possible correlation between lung involvement (assessed by spirometry and HRCT abnormalities) and the serum level of IL-6. 20 patients with scleroderma compared with 20 matched volunteers as control group. All participants underwent spirometry, HRCT scan and serum IL-6 measurements. HRCT signs were scored according to Warrick et al. score for systemic sclerosis. Patients showed a statistically significant reduction in FVC%, FEF 25–75% and significantly higher ESR and IL-6 compared to control. There was a highly significant positive correlation between the total HRCT score and serum IL-6. Serum IL-6 could be a marker of the degree of pulmonary involvement in patients with systemic sclerosis.
ISSN:0422-7638
DOI:10.1016/j.ejcdt.2014.10.004