LTP induction within a narrow critical period of immature stages enhances the survival of newly generated neurons in the adult rat dentate gyrus

Neurogenesis occurs in the adult hippocampus of various animal species. A substantial fraction of newly generated neurons die before they mature, and the survival rate of new neurons are regulated in an experience-dependent manner. Previous study showed that high-frequency stimulation (HFS) of perfo...

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Bibliographic Details
Published in:Molecular brain 2010-04, Vol.3 (1), p.13-13, Article 13
Main Authors: Kitamura, Takashi, Saitoh, Yoshito, Murayama, Akiko, Sugiyama, Hiroyuki, Inokuchi, Kaoru
Format: Article
Language:English
Subjects:
Animals
Brain
Cell Proliferation
Cell Survival
Critical Period (Psychology)
Dentate gyrus
Dentate Gyrus - cytology
Dentate Gyrus - physiology
Electric Stimulation - methods
Electrodes
Experiments
Life sciences
Long-term potentiation
Long-Term Potentiation - physiology
Male
Medical research
Neurogenesis
Neurons
Neurons - cytology
Neurons - physiology
Physiological aspects
Rats
Rats, Wistar
Rodents
Science
Short Report
Time Factors
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Summary:Neurogenesis occurs in the adult hippocampus of various animal species. A substantial fraction of newly generated neurons die before they mature, and the survival rate of new neurons are regulated in an experience-dependent manner. Previous study showed that high-frequency stimulation (HFS) of perforant path fibers to the hippocampal dentate gyrus (DG) induces the long-term potentiation (LTP) in the DG, and enhances the survival of newly generated neurons in the DG. In this study, we addressed whether a time period exists during which the survival of new neurons is maximally sensitive to the HFS. We found that the enhancement of cell survival by HFS was exclusively restricted to the specific narrow period during immature stages of new neurons (7-10 days after birth). Furthermore, the pharmacological blockade of LTP induction suppressed the enhancement of cell survival by the HFS. These results suggest that the LTP induction within a narrow critical period of immature stages enhances the survival of newly generated neurons in rat DG.
ISSN:1756-6606
1756-6606
DOI:10.1186/1756-6606-3-13