Animal models of contraception: utility and limitations

Appropriate animal modeling is vital for the successful development of novel contraceptive devices. Advances in reproductive biology have identified novel pathways for contraceptive intervention. Here we review species-specific anatomic and physiologic considerations impacting preclinical contracept...

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Bibliographic Details
Published in:Open access journal of contraception 2015-01, Vol.6 (default), p.27-35
Main Authors: Liechty, Emma R, Bergin, Ingrid L, Bell, Jason D
Format: Article
Language:English
Subjects:
Birth control
Chlamydia
Clinical trials
Contraceptives
Family planning
Females
Genetic engineering
HIV
Human immunodeficiency virus
Laboratory animals
Physiology
Pregnancy
Primates
Reproductive technologies
Review
Skin
Womens health
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Summary:Appropriate animal modeling is vital for the successful development of novel contraceptive devices. Advances in reproductive biology have identified novel pathways for contraceptive intervention. Here we review species-specific anatomic and physiologic considerations impacting preclinical contraceptive testing, including efficacy testing, mechanistic studies, device design, and modeling off-target effects. Emphasis is placed on the use of nonhuman primate models in contraceptive device development.
ISSN:1179-1527
1179-1527
DOI:10.2147/OAJC.S58754