Analytical study for the charge-transfer complexes of rosuvastatin calcium with π-acceptors

• Published in: Molecules (Basel, Switzerland) Switzerland), 2013-07, Vol.18 (7), p.7711-7725
• Main Authors: Alzoman, Nourah Z, Sultan, Maha A, Maher, Hadir M, Alshehri, Mona M, Wani, Tanveer A, Darwish, Ibrahim A
• Format: Article
• Language: English
• Subjects: Anticholesteremic Agents - chemistry; Anticholesteremic Agents - pharmacology; atherosclerosis; Atherosclerosis - drug therapy; charge-transfer complexes; Chemistry, Pharmaceutical; cholesterol; Cholesterol - biosynthesis; Fluorobenzenes - chemistry; Fluorobenzenes - pharmacology; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - chemistry; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; pharmaceutical analysis; Pyrimidines - chemistry; Pyrimidines - pharmacology; Rosuvastatin Calcium; Spectrophotometry; Sulfonamides - chemistry; Sulfonamides - pharmacology
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules18077711

Studies were carried out to investigate the charge-transfer (CT) reaction of ROS-Ca, as a n-electron donor with various p-acceptors: tetracyanoethylene, p-chloranilic acid, 2,3-dichloro-5,6-dicyano-1,4-benzoquinone, 2,3,5,6-tetrabromo-1,4-benzoquinone, 1,3,5-trinitrobenzene, 2,3,5,6-tetrachloro-1,4-benzoquinone, 7,7,8,8-tetracyano-quinodimethane, and 2,4,7-trinitro-9-fluorenone. Different colored CT complexes were obtained. The reaction mechanism and site of interaction were determined by ultraviolet-visible spectrophotometric techniques and computational molecular modeling. The formation of the colored complexes was utilized in the development of simple, rapid and accurate spectrophotometric methods for the determination of ROS-Ca. Under the optimum reaction conditions, linear relationships with good correlation coefficients (0.9984-0.9995) were found between the absorbances and the concentrations of ROS-Ca in the range of 2-200 mg mL⁻¹. The limits of detection ranged from 0.41 to 12.24 mg mL⁻¹. No interference could be observed from the additives commonly present in the tablets or from the drugs that are co-formulated with ROS-Ca in its combined formulations. The methods were successfully applied to the analysis of tablets with good accuracy and precision; the recovery percentages ranged from 99.54-100.46 ± 1.58-1.82%. The results were compared favorably with the reported method. The proposed methods are practical and valuable for routine application in quality control laboratories for determination of ROS-Ca in its bulk form and tablets.