Keratoconus enlargement as a predictor of keratoconus progression

Numerous approaches have been designated to document progression in keratoconus, nevertheless there is no consistent or clear definition of ectasia progression. In this present study, we aim to evaluate Keratoconus Enlargement (KCE) as a parameter to document ectasia progression. We define KCE as an...

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Bibliographic Details
Published in:Scientific reports 2021-10, Vol.11 (1), p.21079-21079, Article 21079
Main Authors: Cunha, Ana Maria, Correia, Paulo Jorge, Alves, Hélio, Torrão, Luís, Moreira, Raúl, Falcão-Reis, Fernando, Pinheiro-Costa, João
Format: Article
Language:English
Subjects:
692/1807/1482
692/53/2423
692/699/3161/3163
Adolescent
Adult
Astigmatism - diagnostic imaging
Astigmatism - physiopathology
Contact lenses
Cornea
Cornea - diagnostic imaging
Cornea - physiopathology
Corneal Topography
Disease
Disease Progression
Enlargement
Female
Follow-Up Studies
Humanities and Social Sciences
Humans
Keratoconus
Keratoconus - diagnostic imaging
Keratoconus - physiopathology
Longitudinal Studies
Male
multidisciplinary
Ophthalmology
Science
Science (multidisciplinary)
Visual Acuity
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Summary:Numerous approaches have been designated to document progression in keratoconus, nevertheless there is no consistent or clear definition of ectasia progression. In this present study, we aim to evaluate Keratoconus Enlargement (KCE) as a parameter to document ectasia progression. We define KCE as an increase of more than 1D in the anterior curvature of non-apical corneal areas. We have designed a longitudinal study in 113 keratoconic eyes to assess keratoconus progression. KCE was compared with variables commonly used for detection of keratoconus progression like Kmax, Km, K2, PachyMin, D-Index, Corneal Astigmatism and PRC of 3.0 mm centered on the thinnest point. The variations of keratometric readings, D-index and ELEBmax showed positive associations with KCE. Evaluating the performance of Kmax, D-index and KCE as isolated parameters to document keratoconus progression we found a sensitivity of 49%, 82% and 77% and a specificity of 100%, 95% and 66% to detect keratoconus progression (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-00649-0