Oral sucrose and a pacifier for pain relief during simple procedures in preterm infants: a randomized controlled trial

Previous randomized trials of the analgesic effects of sucrose, glucose, and a pacifier in term neonates have shown that the pacifier resulted in lower pain scores than glucose or sucrose, but the pacifier with and without sucrose did not differ. The current study was designed to assess the analgesi...

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Bibliographic Details
Published in:Annals of Saudi medicine 2009-05, Vol.29 (3), p.184-188
Main Authors: Elserafy, Fathia A, Alsaedi, Saad A, Louwrens, Julita, Bin Sadiq, Bakr, Mersal, Ali Y
Format: Article
Language:English
Subjects:
Acute Disease
Administration, Oral
Babies
Behavior
Care and treatment
Double-Blind Method
Follow-Up Studies
Gestational Age
Health aspects
Humans
Infant, Newborn
Infant, Premature
Infants (Premature)
Intensive Care Units, Neonatal
Newborn babies
Original
Pacifiers
Pacifiers (Infant care)
Pain
Pain - etiology
Pain - physiopathology
Pain Management
Pain Measurement
Prospective Studies
Sucking Behavior - physiology
Sucrose
Sucrose - administration & dosage
Sweetening Agents - administration & dosage
Treatment Outcome
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Summary:Previous randomized trials of the analgesic effects of sucrose, glucose, and a pacifier in term neonates have shown that the pacifier resulted in lower pain scores than glucose or sucrose, but the pacifier with and without sucrose did not differ. The current study was designed to assess the analgesic effect of pharmacologic (sucrose, water) and a non-pharmacologic measures (pacifier) in preterm infants and to find whether there is any synergism between these intervention in relieving pain during painful procedures. In this double-blind, randomized, controlled study, 36 preterm infants (mean 31 weeks gestational age, range 27 to 36 weeks) were randomly allocated to six different regimens (0.5 mL sterile water with pacifier, 0.5 mL sterile water without pacifier, 0.5 mL sucrose 24% with pacifier, 0.5 mL sucrose 24% without pacifier, pacifier alone and control group) during a stay in intensive care of up to 15 days. Pain scores were measured with the Premature Infant Pain Profile (PIPP), a validated behavioral acute pain scale. Of all the regimens, the lowest pain scores occurred with the use of 24% sucrose solution combined with pacifier. The mean pain score for the combination of sucrose with pacifier was 0.7 as compared to 1.4 for the sterile water with pacifier group (P
ISSN:0256-4947
0975-4466
DOI:10.4103/0256-4947.52821