Pembrolizumab Therapy Leading to Complete Remission for Recurrence of Pulmonary Metastases after their Resection and Radical Cystectomy following Gemcitabine and Cisplatin Therapy

A 64-year-old man was diagnosed with invasive bladder and right lower ureteral urothelial cancer with right pelvic lymph node and lung metastases. He received four courses of gemcitabine and cisplatin therapy. He underwent lung metastasectomy and radical cystoprostatectomy, with not only primary les...

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Bibliographic Details
Published in:Case reports in urology 2024-01, Vol.2024, p.5586448-4
Main Authors: Ishida, Kyohei, Hasegawa, Go, Hashimoto, Takehisa, Ikeda, Yohei, Hara, Noboru, Nishiyama, Tsutomu
Format: Article
Language:English
Subjects:
Adjuvant treatment
Biomarkers
Bladder cancer
Cancer
Cancer therapies
Case Report
Chemotherapy
Cisplatin
Gemcitabine
Health aspects
Immunotherapy
Lung cancer
Lymphatic system
Medical prognosis
Metastasis
Monoclonal antibodies
Oncology
Patients
Radiation therapy
Remission (Medicine)
Surgery
Targeted cancer therapy
Tumors
Urological surgery
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Summary:A 64-year-old man was diagnosed with invasive bladder and right lower ureteral urothelial cancer with right pelvic lymph node and lung metastases. He received four courses of gemcitabine and cisplatin therapy. He underwent lung metastasectomy and radical cystoprostatectomy, with not only primary lesions but also metastatic lesions showing a complete response. New multiple lung metastases were revealed five months after adjuvant chemotherapy. On starting pembrolizumab therapy, the metastatic lesions are notably reduced in size. He is currently receiving pembrolizumab therapy, and no recurrence has been observed for over one year.
ISSN:2090-696X
2090-6978
DOI:10.1155/2024/5586448