Long-Term Surveillance of Antibiotic Prescriptions and the Prevalence of Antimicrobial Resistance in Non-Fermenting Gram-Negative Bacilli

The increasing emergence of multidrug-resistant (MDR) bacteria has been recognized as a public health threat worldwide. Hospitalized patients and outpatients are commonly infected by non-fermenting Gram-negative bacilli (NFGNB), particularly the - complex (ACB) and . Antimicrobial agents are critica...

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Published in:Microorganisms (Basel) 2020-03, Vol.8 (3), p.397
Main Authors: Chou, Chia-Huei, Lai, Yi-Ru, Chi, Chih-Yu, Ho, Mao-Wang, Chen, Chao-Ling, Liao, Wei-Chih, Ho, Cheng-Mao, Chen, Yu-An, Chen, Chih-Yu, Lin, Yu-Tzu, Lin, Chia-Der, Lai, Chih-Ho
Format: Article
Language:English
Subjects:
acinetobacter calcoaceticus-acinetobacter baumannii complex
Ambulatory care
Amikacin
Antibiotics
Antimicrobial agents
antimicrobial prescription
Antimicrobial resistance
Automation
Bacilli
Bacterial infections
Catheters
Cefepime
Ciprofloxacin
Consent
Drug resistance
Gentamicin
Gram-negative bacilli
Health care facilities
Health insurance
Health risks
Hospitals
Imipenem
Laboratories
Levofloxacin
Meropenem
Multidrug resistance
Nosocomial infection
Nosocomial infections
Pathogens
Patients
Prescriptions
Pseudomonas aeruginosa
Public health
Surveillance
Urine
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Summary:The increasing emergence of multidrug-resistant (MDR) bacteria has been recognized as a public health threat worldwide. Hospitalized patients and outpatients are commonly infected by non-fermenting Gram-negative bacilli (NFGNB), particularly the - complex (ACB) and . Antimicrobial agents are critical for treating the nosocomial infections caused by NFGNB. The aim of this study was to assess antimicrobial resistance and the use of antimicrobial agents. The bacterial isolates of 638,152 specimens from both inpatients and outpatients, retrieved from 2001 to 2008 at a medical center in central Taiwan, were examined for their susceptibility to various antimicrobial agents, including cefepime, imipenem, ciprofloxacin, gentamicin, amikacin, meropenem, and levofloxacin. Administrated prescriptions of the monitored antibiotics were analyzed using the Taiwan National Health Insurance Research Database (NHIRD). Our results show that the defined daily doses (DDDs) for cefepime, imipenem, and ciprofloxacin increased with time, and a trend toward reduced antimicrobial sensitivities of both ACB and was noticeable. In conclusion, the antimicrobial sensitivities of ACB and were reduced with the increased use of antibiotics. Continuous surveillance of antibiotic prescriptions and the prevalence of emerging resistance in nosocomial infections is warranted.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms8030397