Synthesis and antioxidant activity of novel 8-formyl-4-substitued coumarins

4-Methyl-8-formyl- and 4-phenyl-8-formyl coumarins have been synthesized by Pechmann reaction using oxalic acid catalyst for the first time. 4-Propyl-7-hydroxy-, and 4-methyl-7-methoxy coumarins have also been accomplished by this catalyst for the first time. They have been characterizated by IR, [....

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Bibliographic Details
Published in:Bulletin of the Chemical Society of Ethiopia 2018-01, Vol.32 (1), p.175-178
Main Authors: Onar, Hulya Celik, Vardar, Begum Alevli
Format: Article
Language:English
Subjects:
Antioxidant activity
Chemical properties
Chemical synthesis
Coumarin
Coumarins
DPPH method
Methods
Production processes
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Description
Summary:4-Methyl-8-formyl- and 4-phenyl-8-formyl coumarins have been synthesized by Pechmann reaction using oxalic acid catalyst for the first time. 4-Propyl-7-hydroxy-, and 4-methyl-7-methoxy coumarins have also been accomplished by this catalyst for the first time. They have been characterizated by IR, [.sup.1]H-NMR, [.sup.13]C-NMR, mass and elemental analysis. Furthermore, the obtained coumarins were compared according to antioxidant activity by DPPH method. KEY WORDS: Coumarin, Antioxidant activity, DPPH method
ISSN:1011-3924
1726-801X
DOI:10.4314/bcse.v32i1.17